Recruiting

TMS

Sponsor:

University of Minnesota

Code:

NCT04864080

Conditions

Pain

Depression

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Computer game/task

Health surveys online

Study Details

Brief summary:

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Conditions

Pain

Depression

Study ID

NCT04864080

Start date

Apr 11, 2022

Status verified date

Mar, 2026

Completion date

Mar 1, 2027

Anticipated

Primary completion date

Mar 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Arm 1, healthy controls:

Inclusion Criteria:

  • Have access to the online study platform.

Exclusion Criteria:

  • under 18, non-English speaking

Arm 2: pain and depression:

Inclusion Criteria:

  • Pain or depression

Exclusion Criteria:

  • pregnant women

Study Design

Enrollment

45 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

active comparator: Healthy Comparison Group

Behavioral tasks and surveys online.

experimental: Pain/Depression patients from clinic

MRI, TMS and EEG, and behavioral tasks and surveys online.

Interventions

Computer game/task

N-back, COGED, PacMan game, Bandit task, Websurf task.

Health surveys online

Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.

Primary outcome measure

  • Feasibility for all aspects of the study [ Time Frame: 1-7 days ]

Central Contacts and Locations

Central contacts

David Darrow

(612) 624-6666hdlab@umn.edu

MATTHEW D Maple

612-946-1424maple036@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

David Darrow

612-946-1424hdlab@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Mar 4, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-03-04.