Recruiting

Observational Study

Sponsor:

Medical College of Wisconsin

Code:

NCT04892823

Conditions

Hematopoietic and Lymphoid Cell Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Electronic Health Record Review

Questionnaire Administration

Study Details

Brief summary:

This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

Conditions

Hematopoietic and Lymphoid Cell Neoplasm

Study ID

NCT04892823

Start date

May 18, 2021

Status verified date

Aug, 2026

Completion date

Jul 16, 2027

Anticipated

Primary completion date

Jul 16, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aged 18 years and older who are competent to give their informed consent.
  • Ability to read, speak, and understand English.
  • Received a hematopoietic cell transplant within the previous 100 days.

Exclusion Criteria:

  • Less then Aged 18 years and older who are competent to give their informed consent.
  • Cannot read, speak, and understand English.
  • Has not received a hematopoietic cell transplant within the previous 100 days.

Study Design

Enrollment

110 participants

Anticipated

Interventions and Outcome Measures

Arms

Supportive care (EAR, questionnaires, biospecimen collection)

Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Interventions

Biospecimen Collection

Undergo collection of blood sample

Electronic Health Record Review

Review of medical records

Questionnaire Administration

Complete questionnaires

Primary outcome measure

  • The number of participants with gene expression of cellular senescence marker p16. [ Time Frame: Day 100 and 1 year post-transplant ]

Central Contacts and Locations

Central contacts

Medical College of Wisconsin Cancer Center Clinical Trials Office

866-680-0505cccto@mcw.edu

Locations

Froedtert Hospital and the Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Kelly Rentscher, PhD

414-955-8990krentscher@mcw.edu

Principal Investigator:

Kelly Rentscher, PhD

More Information

Sponsor

Medical College of Wisconsin

Last update posted

Aug 5, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2026-08-05.