Recruiting

Genetic Studies

Sponsor:

Columbia University

Code:

NCT04906863

Conditions

Dementia, Early Onset

Alzheimer Dementia (AD)

Mild Cognitive Impairment (MCI)

Memory Loss

Eligibility Criteria

Sex: All

Age: 35+

Healthy Volunteers: Accepted

Interventions

Blood draw

Neurocognitive testing

Medical questionnaire

Study Details

Brief summary:

The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Conditions

Dementia, Early Onset

Alzheimer Dementia (AD)

Mild Cognitive Impairment (MCI)

Memory Loss

Study ID

NCT04906863

Start date

Sep 14, 2016

Status verified date

Apr, 2026

Completion date

Apr 30, 2028

Anticipated

Primary completion date

Apr 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 35+

Healthy Volunteers: Accepted

Inclusion criteria:

  • 35 years and older
  • Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.

Exclusion Criteria:

\- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Mild Cognitive Impairment

Individuals with mild cognitive impairment that began before age 70

Dementia/Alzheimer's Disease

Individuals with Alzheimer's Disease or other dementia that began before age 70

Cognitively Healthy

Cognitively healthy individuals over the age of 35 years with a family history of dementia.

Early-onset dementia prior to the age of 65.

Individuals diagnosed with early-onset dementia prior to the age of 65.

Interventions

Blood draw

Blood draw for identification of genetic variants associated with the development of memory problems

Neurocognitive testing

Brief memory test

Medical questionnaire

Collection of medical history

Primary outcome measure

  • Genetic risk variants associated with early-onset dementia [ Time Frame: 2 years ]
  • Changes in blood biomarkers in early-onset dementia [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Pamela Del Rosario

212-304-7284pd2727@cumc.columbia.edu

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Pamela del Rosario, MD

212-304-7284pd2727@cumc.columbia.edu

Principal Investigator:

Christiane Reitz, MD PhD

More Information

Sponsor

Columbia University

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Keywords

  • Alzheimer's Disease
  • Memory loss
  • Early-onset Alzheimer's disease
  • Mild cognitive impairment
  • Normal cognition
  • Dementia
  • Genetics

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-26. This information was provided to ClinicalTrials.gov by Columbia University on 2026-04-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.