Recruiting

Observational Study

Sponsor:

University of Pennsylvania

Code:

NCT04919538

Conditions

Relapsing Polychondritis

Vasculitis

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints. Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear. The purpose of this study is to study the pathogenesis of RP.

Conditions

Relapsing Polychondritis

Vasculitis

Study ID

NCT04919538

Start date

Feb 26, 2021

Status verified date

Jan, 2026

Completion date

Jan, 2030

Anticipated

Primary completion date

Jan, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 1\. Any subject considered to have a diagnosis of relapsing polychondritis according to the investigator.

Exclusion Criteria:

  • 1\. Inability to provide consent, or in the case of minors, assent.

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Relapsing Polychondritis Cohort

Primary outcome measure

  • Evaluate the pathogenesis of relapsing polychondritis using disease history. [ Time Frame: Study completion; from baseline through month 36. ]

Central Contacts and Locations

Central contacts

Carol McAlear

7813214567cmcalear@upenn.edu

Locations

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Jessica Nguyen

Jessica.Nguyen2@PennMedicine.upenn.edu

More Information

Sponsor

University of Pennsylvania

Last update posted

Jan 23, 2026

Last verified

Jan, 2026

Keywords

  • RP

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-01-23.