Recruiting

Shear-Wave Elastography & Respiratory Function Testing

Sponsor:

Mayo Clinic

Code:

NCT04959526

Conditions

Respiratory Function Loss

Respiratory Complication

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Shear-wave elastography

Study Details

Brief summary:

The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.

Conditions

Respiratory Function Loss

Respiratory Complication

Study ID

NCT04959526

Start date

Jul 28, 2021

Status verified date

Mar, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

\- Adult male and female healthy volunteers.

Exclusion Criteria:

  • Volunteers who are pregnant.
  • Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).

Study Design

Enrollment

24 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Respiratory Function Testing

All subjects will receive standard respiratory function testing and ultrasound-based elastography measurements across various behaviors and conditions

Interventions

Shear-wave elastography

Ultrasound based imaging of diaphragm muscle activity

Primary outcome measure

  • Shear wave speed [ Time Frame: 3 hours ]

Central Contacts and Locations

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Carlos B Mantilla

507-255-1612mantilla.carlos@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

Mar 16, 2026

Last verified

Mar, 2026

Keywords

  • Elastography
  • Ultrasound

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-03-16.