Recruiting
Phase 2

Short Stitch vs. Traditional Suture

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT04982653

Conditions

Liver and Intrahepatic Bile Duct Neoplasm

Metastatic Malignant Neoplasm in the Liver

Primary Malignant Liver Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Quality-of-Life Assessment

Surgical Procedure

Surgical Procedure

Study Details

Brief summary:

This clinical trial compares two different kinds of surgical closing techniques, short stitch suture or traditional suture, in patients who are having liver tumor surgery. This study may help researchers learn if one technique can lower the chances of developing a hole in the wall of the abdomen (an abdominal hernia) at the incision site better than the other.

Conditions

Liver and Intrahepatic Bile Duct Neoplasm

Metastatic Malignant Neoplasm in the Liver

Primary Malignant Liver Neoplasm

Study ID

NCT04982653

Start date

Jan 4, 2022

Status verified date

May, 2026

Completion date

Feb 2, 2027

Anticipated

Primary completion date

Feb 2, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients undergoing hepatectomy for malignant diagnosis (primary or secondary) from 5/1/2021 through 11/1/2024 will be eligible for inclusion in this study
  • Elective surgery
  • Age >= 18
  • Planned midline laparotomy incision or inverted-L incision

Exclusion Criteria:

  • Pre-existing abdominal hernia
  • History of mesh placement at prior laparotomy
  • Pregnant women

Study Design

Enrollment

140 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Arm I (hepatectomy using small bites fascial closure)

Patients undergo hepatectomy as planned using small bites fascial method for abdominal wall closure.

active comparator: Arm II (hepatectomy using conventional fascial method)

Patients undergo hepatectomy as planned using conventional fascial method for abdominal wall closure.

Interventions

Quality-of-Life Assessment

Ancillary studies

Surgical Procedure

Undergo hepatectomy using small bites fascial method for abdominal wall closure

Surgical Procedure

Undergo hepatectomy using conventional fascial method for abdominal wall closure

Primary outcome measure

  • Radiographic incidence rate of incisional hernia [ Time Frame: Up to 12 months after surgery ]

Central Contacts and Locations

Central contacts

Timothy E Newhook, MD

713-792-6940TNewhook@mdanderson.org

Locations

M D Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Timothy E. Newhook

713-792-6940TNewhook@mdanderson.org

Principal Investigator:

Timothy E. Newhook

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

May 26, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-05-26.