Recruiting

COVID-19 Disparities

Sponsor:

National Institute of Environmental Health Sciences (NIEHS)

Code:

NCT04983251

Conditions

Mental Health

Eligibility Criteria

Sex: Female

Age: 18 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Background:

Inequalities in COVID-19 infection, hospitalization, and death in under-studied, under-represented, and under-reported groups of people are severe. A growing number of studies have assessed the impact of individual risk factors. But few studies have assessed which factors are the greatest drivers of COVID-19 disparities from a wider perspective.

Objective:

To understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based programs to help in recovery.

Eligibility:

Healthy people aged 18 and older who reside in North Carolina.

Design:

Participants will take a 45-minute online survey. The survey will cover their demographics, community, health, lifestyle, household, and environment.

Participants may choose to have tests. They may visit the Clinical Research Unit. They may also have a home visit for these tests. In some cases, they may mail samples to the study team in prepaid envelopes.

Participants may take an optional 15 minute survey about their reproductive history.

Participants may give a blood sample.

Participants may give a urine sample. They will fill out a log and return with their sample.

Participants may give saliva samples.

Participants may give toenail samples from each toe.

Participants may give dust samples. They will be given 8 alcohol swabs. Two will be for testing. They will be asked to swipe a total of 3 door frames. Each door frame should be in a different room of the house.

Participants may be given silicone wristbands to wear for 1 week. This is to measure their exposure to air pollutants.

Participants may be contacted in the future for follow-up. They may be contacted by phone, email, or letter.

Conditions

Mental Health

Study ID

NCT04983251

Start date

Jun 30, 2023

Status verified date

Apr 24, 2026

Completion date

Sep 30, 2027

Anticipated

Primary completion date

Sep 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 70+

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Females who are African American or Black, Hispanic or Latino, American Indian or Alaska Native, Asian American, Native Hawaiian or other Pacific Islander.
2. Aged 18 years or older.
3. Reside in North Carolina.
4. Be willing to provide photo ID
5. Able to read and understand English in order to complete surveys (questions validated in English) and logs.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

-Any condition that, in the investigator's opinion, places the participant at undue risk for complications associated with required study procedures.

Study Design

Enrollment

700 participants

Anticipated

Interventions and Outcome Measures

Arms

U4 Women

Women in under-served, under-studied, under-represented, and under-reported (U4) populations.

Primary outcome measure

  • Characterize the mental, physical, and socio-economic effects [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Locations

NIEHS Clinical Research Unit (CRU)

Recruiting

Research Triangle Park, North Carolina, United States, 27709

Contacts

More Information

Sponsor

National Institute of Environmental Health Sciences (NIEHS)

Last update posted

Apr 28, 2026

Last verified

Apr 24, 2026

Keywords

  • Disparities
  • Vaccination
  • COVID-19
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by National Institute of Environmental Health Sciences (NIEHS) on 2026-04-28.