Recruiting

Intercostal Block & Serratus Plane Catheter

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT04990713

Conditions

Video Assisted Thoracic Surgery (VATS)

Pain Management

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Serratus Plane Block (Local Anesthetic) and Intercostal Block (Local Anesthetic)

Serratus Plane Block (Placebo) and Intercostal Block (Local Anesthestic)

Study Details

Brief summary:

Video assisted thoracic surgery (VATS) has emerged as standard of care for majority of thoracic surgeries. It is less invasive compared to thoracotomy and is associated with improved perioperative outcomes \[1-3\]. Good perioperative analgesia after thoracic surgery will enable pulmonary toilet, early chest physiotherapy and mobilisation, \[4,5,6\]. Thirty-day hospital visits and hospital readmissions at London Health Sciences Centre (LHSC) is around 21% and 9% respectively \[7\]. One of the top five determinant for hospital visit and readmission in 30 days, was persistent post operative pain \[7\].

Several options to analgesia are available for patients undergoing VATS procedure. Systemic opioid based multimodal analgesia, central neuraxial blocks like thoracic epidural and peripheral nerve blocks are different available options, and their practise varies across institution \[4,8,9\]. Thoracic epidural or paravertebral blocks can be challenging to perform with high failure rates \[10-12\].

Fascial plane blocks (SAB; ESP) are in vogue in the present era \[13-16\]. They are easy to perform and do not require similar dexterity as needed to perform thoracic epidural or paravertebral blocks. They have minimal side effects and provide the options for continuous infusion for prolonged analgesia. They have become an effective part of multimodal analgesia and have established their roles in ERAS (enhanced recovery after surgery) protocol for VATS procedures.

SAB has become a common practise at our institution with proved clinical efficacy.

Perioperative Surgical Home is a patient centric team-based approach to improve patient's experiences in the perioperative period and thus improve healthcare \[17\]. Quality of Recovery (QoR) is a key determinant to perioperative surgical home and can be measured using the QoR 40 score \[18\]. This is a well validated score with a minimal important clinical difference (MICD) of 6.3 \[19\]. Quality of recovery combines five dimensions of health: patient support, comfort, emotions, physical independence and pain to achieve a single patient outcome - improved patient care \[18\].

The investigators hypothesize the that patients undergoing VATS lung resections using a combination of intercostal nerve block plus continuous SAB catheter infusion of local anesthetics will have a 20% increase in their QoR-40 score 24hour after the surgery compared to a single shot intercostal nerve block.

Conditions

Video Assisted Thoracic Surgery (VATS)

Pain Management

Study ID

NCT04990713

Start date

Jun 30, 2022

Status verified date

Aug, 2025

Completion date

Jan 31, 2026

Anticipated

Primary completion date

Dec 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients undergoing elective VATS lung resections including wedge resection, segmentectomy, bi-lobectomy, or lobectomy.
  • Age > 18 years.
  • ASA (American Society of Anesthesiology) Score - 1 to 4.
  • Gender - all genders
  • Patients able to consent to participate in the study

Exclusion Criteria:

  • Patient refusal to participate in the study.
  • Emergency surgery.
  • Allergies to local anesthetics
  • BMI>40
  • Presence of local (chest wall) or systemic infection.
  • Previous lung resection on the same hemithorax.
  • Patient suffering from chronic pain defined by persistent pain more than six month.
  • Conversion to thoracotomy

Study Design

Enrollment

200 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

placebo comparator: Serratus Plane Block (Placebo) and Intercostal Block (Local Anesthestic)

Patients randomized to this group will receive the intercostal block with local anesthetic and the serratus plane block with saline placebo. Local anesthetic administered will be ropivacaine 0.2%.

experimental: Serratus Plane Block (Local Anesthetic) and Intercostal Block (Local Anesthetic)

Patients randomized to this group will receive the intercostal block with local anesthetic and the serratus plane block with local anesthetic. Local anesthetic administered will be ropivacaine 0.2%.

Interventions

Serratus Plane Block (Local Anesthetic) and Intercostal Block (Local Anesthetic)

Patients will receive local anesthetic via serratus plane block as opposed to saline placebo

Serratus Plane Block (Placebo) and Intercostal Block (Local Anesthestic)

Patients will receive saline placebo via serratus plane block

Primary outcome measure

  • Quality of Recovery [ Time Frame: Measured on postoperative day 1 ]

Central Contacts and Locations

Central contacts

Locations

London Health Sciences Centre

Recruiting

London, Ontairo, Canada, N6A 5A5

Contacts

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Sep 4, 2025

Last verified

Aug, 2025

Keywords

  • Intercostal Block
  • Fascial Plane Block

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2025-09-04.