Recruiting

Observational Study

Sponsor:

University of Pennsylvania

Code:

NCT04997642

Conditions

Parkinson Disease

Parkinson Disease Dementia

Lewy Body Parkinson Disease

Lewy Body Dementia With Behavioral Disturbance

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

neuropsychiatric and cognitive testing questionnaires

Study Details

Brief summary:

The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with Parkinson's disease and related disorders receiving care at the Parkinson's disease and Movement Disorders Center and the Hospital of the University of Pennsylvania.

Conditions

Parkinson Disease

Parkinson Disease Dementia

Lewy Body Parkinson Disease

Lewy Body Dementia With Behavioral Disturbance

Study ID

NCT04997642

Start date

Sep 30, 2019

Status verified date

Oct, 2025

Completion date

Sep 15, 2029

Anticipated

Primary completion date

Sep 15, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Any person who receives medical care for the diagnosis of Parkinson's disease with mild cognitive impairment (MCI) or dementia may be eligible to participate in the research database. There are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments.

Exclusion Criteria:

Absence of Parkinson's disease diagnosis. There are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments.

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Interventions

neuropsychiatric and cognitive testing questionnaires

Demographic data such as race, sex, age Family History Risk Factor Questionnaire Hoehn and Yahr Stage UPDRS Parkinson's symptom checklist Medication list Neuropsychological Test Battery Behavioral Exams

  • Geriatric Depression Scale Quality of Life Questionnaire
  • PDQ-39, SF-12

Primary outcome measure

  • Long term effects of Parkinson's disease [ Time Frame: 5 years ]
  • Genetic and Neurobiological factors [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Eugenia Mamikonyan

215-615-3085eugenia.mamikonyan@pennmedicine.upenn.edu

Locations

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Sarah Shaw

215-615-0838sarah.shaw@pennmedicine.upenn.edu

Gina Mamikonyan

215-615-3085eugeniam@pennmedicine.upenn.edu

More Information

Sponsor

University of Pennsylvania

Last update posted

Oct 7, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2025-10-07.