Recruiting

Pain Stimulation

Sponsor:

Université de Sherbrooke

Code:

NCT05006066

Conditions

Healthy

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Temporal Summation

Study Details

Brief summary:

Temporal summation is a mechanism that enhances pain perception. It is a natural mechanism present in most individuals. Generally, temporal summation is measured by the application of a moderately painful stimulation for several seconds.However, there is still no official recommendation in the literature. There is therefore a great disparity in the protocols. Some studies apply thermal stimulation (heating the skin) while others apply mechanical stimulation (applying pressure). Another point of contention is that some studies apply continuous stimulation for 2 minutes while others apply a series of several small stimulation of 1 second). Between these studies, the amplitude of temporal summation varies according to the stimulation performed. Note also that the study population is also very different between studies. In these conditions, it remains difficult to know the impact of the nature of the stimulation on the measured amplitude of the temporal summation.

Conditions

Healthy

Study ID

NCT05006066

Start date

Jul 12, 2021

Status verified date

May, 2022

Completion date

Aug 30, 2022

Anticipated

Primary completion date

Aug 30, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subjects aged 18 to 30 years, able to consent (understand English or French)
  • No chronic pain
  • No primary sensory disorders

Exclusion Criteria:

  • Presence of upper extremity injuries
  • Absence of anxiety symptoms (HADs Score < 6) (Appendix 1)
  • Presence of cardiovascular disease / neurocognitive disorders / mental illness
  • Pregnant or postpartum women less than one year old

Study Design

Enrollment

34 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy volunteers - Pain-Free

Each participant will be stimulated with 4 temporal summation stimulation conditions:

  • continuous thermal (1 stimulation of two minutes)
  • repetitive thermal (30 stimulations of 1 second)
  • continuous mechanical (1 stimulation of two minutes)
  • repetitive mechanical (30 stimulation of 1 second)

Interventions

Temporal Summation

4 type of stimulations applied on the right arm

Primary outcome measure

  • Temporal Summation of Pain - repetitive thermal stimulation [ Time Frame: During stimulation ]
  • Temporal Summation of Pain - continuous thermal stimulation [ Time Frame: During stimulation ]
  • Temporal Summation of Pain - continuous mechanical stimulation [ Time Frame: During stimulation ]
  • Temporal Summation of Pain - repetitive mechanical stimulation [ Time Frame: During stimulation ]

Central Contacts and Locations

Central contacts

Locations

Université de Sherbrooke

Recruiting

Sherbrooke, Quebec, Canada, JH1 5N4

Contacts

More Information

Sponsor

Université de Sherbrooke

Last update posted

May 19, 2022

Last verified

May, 2022

Keywords

  • Temporal Summation
  • Mechanical Stimulation
  • Heat Pain Stimulation
  • Thermode

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Université de Sherbrooke on 2022-05-19.