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Early Phase 1

Observational Study

Sponsor:

Madigan Army Medical Center

Code:

NCT05024760

Conditions

Peri-Implantitis

Peri-implant Mucositis

Implant Infection

Dental Implant Failed

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Chlorhexidine

Hydrogen Peroxide

Study Details

Brief summary:

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

Conditions

Peri-Implantitis

Peri-implant Mucositis

Implant Infection

Dental Implant Failed

Study ID

NCT05024760

Start date

Jul 28, 2022

Status verified date

Jul, 2026

Completion date

May 1, 2026

Primary completion date

Dec 31, 2025

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Active duty military
  • 18-55 years old
  • Over 6 months remaining at local duty station

Exclusion Criteria:

  • Tobacco user
  • Medications that affect soft tissue or bone healing
  • Metabolic disorder that affects soft tissue or bone healing
  • Active periodontal disease

Study Design

Enrollment

97 participants

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: Control

This arm will receive standard of care during dental implant insertion.

experimental: Chlorhexidine

Chlorhexidine treatment.

experimental: Hydrogen Peroxide

Hydrogen Peroxide treatment.

Interventions

Chlorhexidine

Chlorhexidine will be inserted into the dental implant internal cavity during dental implant insertion.

Hydrogen Peroxide

Hydrogen Peroxide will be inserted into the internal cavity of the dental implant during dental implant insertion.

Primary outcome measure

  • Implant Failure [ Time Frame: Four months post dental implant insertion. ]

Central Contacts and Locations

More Information

Sponsor

Madigan Army Medical Center

Last update posted

Jul 22, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-19. This information was provided to ClinicalTrials.gov by Madigan Army Medical Center on 2026-07-22.