Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT05065151

Conditions

Parkinson Disease

Deep Brain Stimulation

Motivation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Stimulation on

Stimulation off

Decision Making Task

Study Details

Brief summary:

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.

Conditions

Parkinson Disease

Deep Brain Stimulation

Motivation

Study ID

NCT05065151

Start date

Oct 30, 2021

Status verified date

Jun, 2026

Completion date

Dec 1, 2030

Anticipated

Primary completion date

Dec 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Has Parkinson's Disease or Dystonia
  • Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN
  • Has DBS device implanted either bilaterally or unilaterally
  • Male or female
  • More than 1 month post-DBS surgery

Exclusion Criteria:

  • Severe cognitive impairments
  • Has MOCA score below 20
  • Pregnancy
  • Age less than 18 years old

Study Design

Enrollment

70 participants

Anticipated

Allocation

Non randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Stimulation

Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept device.

experimental: No Stimulation

Patients will have stimulation turned off through their Medtronic Percept device.

Interventions

Stimulation on

Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.

Stimulation off

Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.

Decision Making Task

Patients will be playing a decision making task through a computer-based application.

Primary outcome measure

  • Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease Patients [ Time Frame: The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years ]
  • Percent of Risky Decisions made with Percept DBS stimulation off for Parkinson's Disease Patients [ Time Frame: The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years ]
  • Reaction Time During Decision-Making Task [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Task Success Rate [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Acceptance Rate of Risky Versus Safe Options [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Force Exertion During Motor Responses [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Low frequency local field potentials [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Electroencephalogram (EEG) theta band power [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Electroencephalogram (EEG) beta band power [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Electroencephalogram (EEG) gamma band power [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]
  • Electroencephalogram (EEG) alpha band power [ Time Frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years. ]

Central Contacts and Locations

Central contacts

Sarah Wang, PhD

415-353-7885Sarah.Wang@ucsf.edu

Locations

University of California San Francisco

Recruiting

San Francisco, California, United States, 94158

Contacts

Sarah Wang, PhD

415-353-7885Sarah.Wang@ucsf.edu

Principal Investigator:

Simon J Little, MBBS, PhD

More Information

Sponsor

University of California, San Francisco

Last update posted

Jun 5, 2026

Last verified

Jun, 2026

Keywords

  • Parkinson's
  • Medtronic
  • Percept
  • DBS
  • Deep Brain Stimulation
  • Parkinson's Disease
  • Parkinson Disease
  • PD
  • Reward-based decision making
  • Task

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-06-05.