Recruiting

Observational Study

Sponsor:

University of Illinois at Chicago

Code:

NCT05067179

Conditions

Amyotrophic Lateral Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's Disease, is a progressive, terminal condition of muscle weakness that is associated with degeneration of neurons in the spinal cord and brain. This devastating disorder afflicts people in the prime of their lives. At the present time, there are no cures for this disorder, and current treatments are marginal at best. Despite years of intensive research, a fundamental understanding of this disease is still lacking. There is a need to identify both reliable markers of disease progression and effective treatments. The goal of this research is to bring a greater understanding of ALS patients closer to the research studies that can lead to new hypotheses and approaches.

Conditions

Amyotrophic Lateral Sclerosis

Study ID

NCT05067179

Start date

Sep 1, 2020

Status verified date

Jul, 2026

Completion date

Jan 1, 2030

Anticipated

Primary completion date

Jan 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients over the age of 18
  • Established diagnosis of ALS
  • Able and willing to give written informed consent and must authorize release and use of protected health information

Exclusion Criteria:

  • Patients below the age of 18
  • No diagnosis of ALS

Study Design

Enrollment

40 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Imaging biomarkers [ Time Frame: Within 6 months of participant enrollment ]
  • Molecular biomarkers [ Time Frame: Within 12 months of participant's passing ]

Central Contacts and Locations

Central contacts

Locations

University of Illinois at Chicago

Recruiting

Chicago, Illinois, United States, 60612

Contacts

More Information

Sponsor

University of Illinois at Chicago

Last update posted

Jul 8, 2026

Last verified

Jul, 2026

Keywords

  • Amyotrophic Lateral Sclerosis (ALS)
  • Lou Gehrig's Disease
  • Neurodegenerative Diseases
  • Neuromuscular Diseases
  • Nervous System Diseases

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Illinois at Chicago on 2026-07-08.