Recruiting

Observational Study

Sponsor:

Ann & Robert H Lurie Children's Hospital of Chicago

Code:

NCT05120518

Conditions

Pediatric Cancer

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Collection of post mortem tissue donation

Study Details

Brief summary:

The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).

Conditions

Pediatric Cancer

Study ID

NCT05120518

Start date

Aug 14, 2019

Status verified date

Jun, 2026

Completion date

Aug 14, 2029

Anticipated

Primary completion date

Aug 14, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology)
  • Signed consent for post mortem tissue donation and autopsy

Exclusion Criteria:

  • Signed consent for post mortem tissue donation and autopsy not obtained

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

Pediatric patients with cancer and non-cancer tumor types

Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology and stem cell)

Interventions

Collection of post mortem tissue donation

Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.

Primary outcome measure

  • Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent [ Time Frame: Up to 5 years from procurement ]

Central Contacts and Locations

Central contacts

Angela Waanders, MD

312-227-4090awaanders@luriechildrens.org

Melissa Williams, BA

312-227-3893mjwilliams@luriechildrens.org

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Angela Waanders, MD

312-227-4090awaanders@luriechildrens.org

Melissa Williams, BA

312-227-3893mjwilliams@luriechildrens.org

More Information

Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago

Last update posted

Jun 3, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Ann & Robert H Lurie Children's Hospital of Chicago on 2026-06-03.