Recruiting

AVOID & RESIST

Sponsor:

Cedars-Sinai Medical Center

Code:

NCT05143931

Conditions

Obesity

Overweight

Eligibility Criteria

Sex: All

Age: 14+

Healthy Volunteers: Accepted

Interventions

Home food environment and grocery delivery (AVOID)

Inhibitory control training (RESIST)

WW

Study Details

Brief summary:

The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an impulse control training strategy (RESIST).

Conditions

Obesity

Overweight

Study ID

NCT05143931

Start date

Jun 6, 2022

Status verified date

Feb, 2026

Completion date

Feb 9, 2027

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14+

Healthy Volunteers: Accepted

Inclusion Criteria (Main participants):

  • Age 18 years or older
  • BMI between 25-45 kg/m2
  • Read, write, and speak English with acceptable visual acuity
  • Has a household member (≥ 14 years) willing to complete three brief assessments over 12 months\* \*Only applies to individuals who indicate they are cohabitating with at least one eligible household member

Inclusion Criteria (Household participants):

  • 14-years-old
  • Parent consent for children <18-years-old
  • Willingness to complete assessments / measurements

Exclusion Criteria (Main participants):

  • Currently enrolled in weight loss interventions or undergoing bariatric surgery
  • Pregnant women
  • Individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug/alcohol abuse)
  • Individuals with severe cognitive delays or visual/hearing impairment
  • Individuals who are unable or unwilling to complete the study assessments / measurements

Exclusion Criteria (Household participants):

  • ≤ 14-years-old
  • Individuals who are unable or unwilling to complete the study assessments / measurements

Study Design

Enrollment

503 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: WW Only

WW is commercially-available weight management program focusing on diet, physical activity and mindset skills.

experimental: WW + Home modification and grocery delivery (AVOID)

WW + modification of home food environment + online grocery shopping and delivery

experimental: WW + Inhibitory control training (RESIST)

WW + daily gamified inhibitory control training

experimental: WW + Home food modification and grocery delivery (AVOID) + Inhibitory control training (RESIST)

WW + modification of home food environment + online grocery shopping and delivery + daily gamified inhibitory control training

Interventions

Home food environment and grocery delivery (AVOID)

Participants (Arms 2 \& 4) will receive 6 months of coaching (Zoom and/or email/text) to modify their home food environment and alter cues to promote healthy food choices

Inhibitory control training (RESIST)

Participants assigned to RESIST (Arms 3 \& 4) will receive 6 months of coaching (Zoom and/or email/text) and gamified inhibitory control training.

WW

Participants assigned to all arms will receive 6 months of coaching (Zoom and/or email/text) and commercially-available weight management program focusing on diet, physical activity and mindset skills.

Primary outcome measure

  • Change in BMI from baseline to 12 months. [ Time Frame: Baseline, 6-month, 12-month ]

Central Contacts and Locations

Central contacts

Julissa Ruiz, BS

(310) 602-4169julissa.ruiz@cshs.org

Jessica Capaldi, MS

310.218.5560Jessica.Capaldi@cshs.org

Locations

Cedars-Sinai Medical Center

Recruiting

Los Angeles, California, United States, 90069

Contacts

Julissa Ruiz

(310) 602-4169julissa.ruiz@cshs.org

Principal Investigator:

Sarah J Salvy, PhD

More Information

Sponsor

Cedars-Sinai Medical Center

Last update posted

Feb 17, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Cedars-Sinai Medical Center on 2026-02-17.