Recruiting

Optical Coherence Tomography

Sponsor:

Johns Hopkins University

Code:

NCT05171478

Conditions

Lung Cancer

Sarcoidosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Full-field optical coherence tomography

Study Details

Brief summary:

This study sets out to register imaging of small biopsy specimens obtained during bronchoscopy using full-field optical coherence tomography against standard histologic evaluation.

Conditions

Lung Cancer

Sarcoidosis

Study ID

NCT05171478

Start date

Dec 9, 2021

Status verified date

Dec, 2025

Completion date

Dec 8, 2026

Anticipated

Primary completion date

Dec 8, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Inpatients or outpatients greater than or equal to 18 years old
  • Capable of providing informed consent
  • Undergoing bronchoscopy for diagnosis or staging per standard of care
  • Collection of small biopsy samples by EBUS or conventional transbronchial needle aspiration (TBNA) or transbronchial biopsy for purposes outside of the research study

Exclusion Criteria:

  • Standard contraindications bronchoscopy including bleeding disorders, antiplatelet or anticoagulant usage, severe respiratory failure, and clinical instability
  • Pregnancy

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Interventions

Full-field optical coherence tomography

Sample obtained during bronchoscopy will be imaged using full-field optical coherence tomography

Primary outcome measure

  • Correlation of FFOCT to standard histology as assessed by the kappa value [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Jeffrey Thiboutot, MD

410-502-2533jthibou1@jhmi.edu

Locations

Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

IP Research Team

410-955-6105ipresearch@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Dec 17, 2025

Last verified

Dec, 2025

Keywords

  • lung cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2025-12-17.