Recruiting

Beta-Blocker Withdrawal

Sponsor:

UConn Health

Code:

NCT05174351

Conditions

Heart Failure With Preserved Ejection Fraction

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Interventions

beta blocker discontinuation

Study Details

Brief summary:

This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

Conditions

Heart Failure With Preserved Ejection Fraction

Study ID

NCT05174351

Start date

Dec 20, 2021

Status verified date

Jul, 2025

Completion date

Nov 1, 2027

Anticipated

Primary completion date

Nov 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
  • N=30 (Target: 30).
  • Age: 50 \~ 80 years.
  • ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
  • Chronic loop diuretic use
  • Currently on beta-blocker

Exclusion Criteria:

  • Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
  • Heart rate > 100 bpm
  • Recent hospitalization due to HF within 3 months
  • Non-English speaker

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: HFpEF patients

HFpEF patient who are currently taking beta blockers

Interventions

beta blocker discontinuation

beta blocker discontinuation

Primary outcome measure

  • Changes in KCCQ-23 score [ Time Frame: Baseline and after 4 weeks of beta blocker discontinuation ]

Central Contacts and Locations

Central contacts

Kai Chen, MD,PhD

860-679-3343kachen@uchc.edu

Locations

UConn Health / John Dempsey Hospital

Recruiting

Farmington, Connecticut, United States, 06030

Contacts

Kai Chen, MD, PhD

860-679-3343kachen@uchc.edu

More Information

Sponsor

UConn Health

Last update posted

Sep 29, 2025

Last verified

Jul, 2025

Keywords

  • HFpEF
  • Beta-blocker
  • echocardiogram
  • 6MWT

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by UConn Health on 2025-09-29.