Recruiting

Exercise

Sponsor:

University of Alberta

Code:

NCT05188014

Conditions

Type 1 Diabetes

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Not accepted

Interventions

Luteal Phase Aerobic Exercise

Follicular Phase Aerobic Exercise

Study Details

Brief summary:

Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during the no pill/placebo pill phase of the menstrual cycle). An exercise session (45 minutes of aerobic exercise at 60% VO2peak on a cycle ergometer) will take place at 5 pm on the second day of glucose monitoring.

Conditions

Type 1 Diabetes

Study ID

NCT05188014

Start date

Mar 15, 2022

Status verified date

Jul, 2026

Completion date

Aug 30, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • type 1 diabetes diagnosed for at least 1 year
  • regular menses
  • using monophasic oral contraceptives
  • residing in Edmonton, Alberta and able to visit the lab at the University of Alberta

Exclusion Criteria:

  • HbA1c > 9.9%
  • frequent and unpredictable hypoglycemia
  • change in insulin management strategy within two months of the study
  • use of an automated insulin delivery system
  • blood pressure > 140/95
  • history of cardiovascular disease
  • severe peripheral neuropathy
  • active proliferative retinopathy
  • use of medications (other than insulin) that would affect blood glucose levels
  • any musculoskeletal condition that would contraindicate exercise (e.g. sprain, strain, joint injury, etc.)

Study Design

Enrollment

15 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: All participants

All participants will be in a single study arm.

Interventions

Luteal Phase Aerobic Exercise

Participants will perform 45 minutes of moderate (60% VO2peak) aerobic exercise on a cycle ergometer during the last week of active pill consumption.

Follicular Phase Aerobic Exercise

Participants will perform 45 minutes of moderate (60% VO2peak) aerobic exercise on a cycle ergometer within 5 days of starting their menses.

Primary outcome measure

  • Blood glucose [ Time Frame: Pre-exercise (0 minutes), post-exercise (45 minutes) and 1 hour post-exercise ]

Central Contacts and Locations

Locations

Alberta Diabetes Institute

Recruiting

Edmonton, Alberta, Canada, T6G 2R3

Contacts

Jane E Yardley, PhD

7806791688jane.yardley@ualberta.ca

More Information

Sponsor

University of Alberta

Last update posted

Jul 20, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alberta on 2026-07-20.