Recruiting

Aerobic vs. Resistance

Sponsor:

University of Alberta

Code:

NCT05188027

Conditions

Type 1 Diabetes

Post-menopause

Eligibility Criteria

Sex: Female

Age: 45 - 70+

Healthy Volunteers: Not accepted

Interventions

Aerobic Exercise

Resistance Exercise

No exercise

Study Details

Brief summary:

Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third will be a moderate weight-lifting session (\~30 minutes of exercise, 60 minutes of recovery).The investigators will measure changes in blood glucose during exercise by drawing blood during and after exercise. Post-exercise glucose trends will be examined using continuous glucose monitoring.

Conditions

Type 1 Diabetes

Post-menopause

Study ID

NCT05188027

Start date

Nov 16, 2021

Status verified date

Mar, 2026

Completion date

Mar 30, 2027

Anticipated

Primary completion date

Mar 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 45 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • type 1 diabetes, diagnosed for at least one year
  • post-menopause (at least one year since last menstrual period), or have had a hysterectomy and bilateral salpingo oophorectomy
  • able to perform aerobic and resistance exercise
  • able to visit the lab in Edmonton, Alberta (University of Alberta)

Exclusion Criteria:

  • HbA1c > 9.9 %
  • frequent and unpredictable hypoglycemia
  • change in insulin management strategy within the last 2 months
  • blood pressure > 140 / 95
  • severe peripheral neuropathy
  • history of cardiovascular disease
  • musculoskeletal injuries interfering with exercise performance
  • use of medications (other than insulin) that affect glucose metabolism
  • BMI > 30 kg/m2
  • smoking
  • moderate to high alcohol intake (> 2 drinks/day)

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: All participants

All participants will take part in all three testing conditions

Interventions

Aerobic Exercise

Walking at 60% of maximal aerobic capacity on a treadmill

Resistance Exercise

Performing one set of 10 repetitions of 10 different weight-lifting exercises

No exercise

Participants will rest in a supine position for 30 minutes.

Primary outcome measure

  • Blood glucose [ Time Frame: From 0 minutes to 45 minutes (beginning to the end of exercise/control) and then for 60 minutes after exercise ]

Central Contacts and Locations

Central contacts

Jane E Yardley, PhD

780-679-1688jane.yardley@ualberta.ca

Locations

Alberta Diabetes Institute

Recruiting

Edmonton, Alberta, Canada, T6G 2R3

Contacts

Jane E Yardley, PhD

7806791688jane.yardley@ualberta.ca

Institut de recherches cliniques de Montréal

Recruiting

Montreal, Quebec, Canada, H2W 1R7

Contacts

Jane Yardley, PhD

jane.yardley@ircm.qc.ca

More Information

Sponsor

University of Alberta

Last update posted

Mar 16, 2026

Last verified

Mar, 2026

Keywords

  • Exercise
  • Physical activity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alberta on 2026-03-16.