Recruiting

Radiofrequency Ablation

Sponsor:

Columbia University

Code:

NCT05189808

Conditions

Indeterminate Bethesda III Thyroid Nodules

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Radiofrequency Ablation

Study Details

Brief summary:

The purpose of this observational chart review study is to evaluate the efficacy and safety of Radiofrequency Ablation (RFA) for treatment of indeterminate thyroid nodules before and after RFA procedure. This is a data collection study in which the investigators ask patients to give access to information generated before and after RFA treatment of their condition. The RFA procedure uses image guidance to place an electrode through the skin into the target area. In RFA, high-frequency electrical currents are passed through an electrode, creating a small region of heat to treat the lesion.

Conditions

Indeterminate Bethesda III Thyroid Nodules

Study ID

NCT05189808

Start date

Aug 1, 2020

Status verified date

May, 2026

Completion date

Aug, 2028

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Indeterminate Bethesda III nodules that have been molecularly profiled benign with either Afirma Genomic Sequencing Classifier (GSC) or ThyroSeq v3 tests

Exclusion Criteria:

  • cardiac arrthymias
  • pregnancy

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Group

Interventions

Radiofrequency Ablation

Ultrasound guided radiofrequency ablation (non-experimental)

Primary outcome measure

  • Change in Nodule Volume [ Time Frame: 12 months ]

Central Contacts and Locations

Central contacts

Jennifer H Kuo, MD MS

212-305-6969jhk2029@cumc.columbia.edu

Catherine McManus, MD MS

212-305-6969cm3304@cumc.columbia.edu

Locations

Columbia University

Recruiting

New York, New York, United States, 10032

Contacts

Jennifer H Kuo, MD MS

212-305-6969jhk2029@cumc.columbia.edu

More Information

Sponsor

Columbia University

Last update posted

May 29, 2026

Last verified

May, 2026

Keywords

  • Radiofrequency Ablation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-05. This information was provided to ClinicalTrials.gov by Columbia University on 2026-05-29.