Recruiting

RFA

Sponsor:

Columbia University

Code:

NCT05189821

Conditions

Papillary Thyroid Microcarcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Radiofrequency Ablation

Study Details

Brief summary:

Thyroid surgery has always been the mainstay of treatment for thyroid cancer. Thyroid surgery carries a low risk of complications that include recurrent or superior laryngeal nerve injury leading to voice changes, hypoparathyroidism, hypothyroidism with need for thyroid hormone supplementation, and unsightly scarring. Although many patients with thyroid cancer find these risks acceptable, these risks are sometimes less acceptable to patients with benign disease. In an era when the medical field is treating thyroid diseases less aggressively, there is a pressing need to identify approaches to treat indolent malignant disease less invasively.

The purpose of this observational study is to evaluate the efficacy and safety of Radiofrequency Ablation (RFA) for treatment of Papillary Thyroid Microcarcinoma (PTMC) in patients that have already agreed to RFA procedure based on treating physician recommendation. This is a data collection study in which we ask participants to give us access to information generated before and after RFA treatment of their condition. The RFA procedure uses image guidance to place an electrode through the skin into the target tumor. In RFA, high-frequency electrical currents are passed through an electrode, creating a small region of heat to treat the lesion.

Conditions

Papillary Thyroid Microcarcinoma

Study ID

NCT05189821

Start date

Nov 1, 2021

Status verified date

May, 2026

Completion date

Nov, 2028

Anticipated

Primary completion date

Nov, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients (>/= 18 years)
  • Biopsy proven papillary thyroid microcarcinoma (>/= 1.5cm in greatest diameter, PTMC)
  • Either refuse surgery or are not good surgical candidates

Exclusion Criteria:

  • Cardiac arrhythmia
  • Pregnancy

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Interventions

Radiofrequency Ablation

Ultrasound guided radiofrequency ablation

Primary outcome measure

  • Complete sonographic disappearance (CD) [ Time Frame: 12 months ]

Central Contacts and Locations

Central contacts

Locations

Columbia University

Recruiting

New York, New York, United States, 10032

Contacts

More Information

Sponsor

Columbia University

Last update posted

May 29, 2026

Last verified

May, 2026

Keywords

  • Radiofrequency Ablation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2026-05-29.