Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT05193305

Conditions

Healthy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Cancer produces a significant burden on society with a majority diagnosed at late stages when the chance of cure is low. Early diagnosis improves patient outcomes. Data consisting of lifestyle factors, medications, physical activity, years before conventional cancer diagnosis is also worthwhile for to determine early detection. This is only achievable with longitudinal tracking of a large number of healthy individuals and identifying those who do develop cancer over time.

Conditions

Healthy

Study ID

NCT05193305

Start date

Feb 1, 2023

Status verified date

Feb, 2026

Completion date

Feb 28, 2043

Anticipated

Primary completion date

Feb 28, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All adults 18 years of age of older undergoing upper or lower endoscopy for routine medical care.

Exclusion Criteria:

  • Persons with current malignancy
  • Persons with history of malignancy and treatment within last 5 years of enrollment, excluding non-melanoma skin cancer or cervical in-situ.
  • Persons who are unable or unwilling to provide repeat blood samples and complete follow-up questionnaires
  • Persons who lack the capacity to provide consent
  • Persons who do not speak English
  • Persons who are visually or hearing impaired.

Study Design

Enrollment

10000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Development of malignancy [ Time Frame: Up to 20 years ]

Central Contacts and Locations

Central contacts

Elham Afghani

410-955-5000eafghan1@jhmi.edu

Locations

Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21205

More Information

Sponsor

Johns Hopkins University

Last update posted

Feb 25, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-02-25.