Recruiting

Observational Study

Sponsor:

Ann & Robert H Lurie Children's Hospital of Chicago

Code:

NCT05199532

Conditions

Eosinophilic Esophagitis

Eosinophilic Gastroenteritis

Eosinophilic Colitis

Eosinophilic Gastrointestinal Disease

Eligibility Criteria

Sex: All

Age: 1 - 25

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to learn more about Eosinophilic Gastrointestinal Disorders (EGIDs). With this registry we hope to find out more about the symptoms that patients have during their treatment, the quality of life they have with the diagnosis, what the disease looks like throughout the different treatment methods, and if there is a connection between EGIDs and connective tissue disorders.

The goal of this study is to be able to better understand EGIDs and use information gained from all the information collected on this study for more precise treatments in the future. We want to create a large collection of samples, called a biorepository, to learn the most about EGIDs as possible. When the samples are collected, which will occur at procedures directed by your child's doctor as part of their standard of care, they will be stored for an unlimited amount of time to perform experiments on these samples and to gather information about EGIDs

Conditions

Eosinophilic Esophagitis

Eosinophilic Gastroenteritis

Eosinophilic Colitis

Eosinophilic Gastrointestinal Disease

Study ID

NCT05199532

Start date

Dec 18, 2020

Status verified date

Mar, 2026

Completion date

Dec, 2035

Anticipated

Primary completion date

Nov, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 1 - 25

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with an established diagnosis of an EGID, based on pathology findings from an endoscopy or colonoscopy with biopsies.
  • Patients suspected of having an EGID and undergoing endoscopic evaluation for further assessment

Exclusion Criteria:

  • Patients who do not consent to participate

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Clinical/Patient-Reported Measures [ Time Frame: through study completion, an average of 6 months to 1 year ]
  • Endoscopic measures [ Time Frame: through study completion, an average of 6 months to 1 year ]
  • Physical exam findings [ Time Frame: through study completion, an average of 6 months to 1 year ]
  • Histologic features [ Time Frame: through study completion, an average of 6 months to 1 year ]
  • Molecular measures [ Time Frame: through study completion, an average of 6 months to 1 year ]

Central Contacts and Locations

Central contacts

Angela Anthony

312-227-4559aanthony@luriechildrens.org

Mary Riordan

312-227-4558mriordan@luriechildrens.org

Locations

Ann & Robert H Lurie Children's Hospital of Chicago

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Zeinab Dehghani, MD

312-227-4656zdehghani@luriechildrens.org

Angela Anthony

312-227-4559aanthony@luriechildrens.org

Principal Investigator:

Joshua B Wechsler, MD

More Information

Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago

Last update posted

Mar 18, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-10. This information was provided to ClinicalTrials.gov by Ann & Robert H Lurie Children's Hospital of Chicago on 2026-03-18. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.