Recruiting

Observational StudySensorimotor Integration Underlying Balance Control in Individuals With Incomplete Spinal Cord Injury

Sponsor:

Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

Code:

NCT05200091

Conditions

Spinal Cord Injuries

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Combined explosive strength and specific balance training group

Study Details

Brief summary:

The objectives of the study are to evaluate a 4-week mixed training paradigm consisting of explosive strength training and balance perturbation training efficacy on balance control during standing and locomotion, and to understand the mechanisms of neuroplasticity that would improve sensorimotor integration at supraspinal and spinal levels.

Conditions

Spinal Cord Injuries

Study ID

NCT05200091

Start date

Jul 9, 2018

Status verified date

Jan, 2022

Completion date

Dec, 2022

Anticipated

Primary completion date

Dec, 2022

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

FOR PARTICIPANTS WITH SPINAL CORD INJURY

Inclusion Criteria:

Have an incomplete lesion of spinal cord
Level of spinal cord lesion between C5 and T12
At least, 6 months post-injury
Be considered as AIS C or D
Be able to stand without support for 15 seconds
Be able to provide informed consent in English or in French

Exclusion Criteria:

To have cognitive deficits
To have personal or family history of epilepsy
To have suffered moderate or severe traumatic brain injury
To have cochlear implant

FOR CONTROL PARTICIPANTS

Exclusion Criteria:

To have orthopedics problems
To have cognitive deficits
To have neurological problems

Study Design

Enrollment

36 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Combined explosive strength and specific balance training group

This group will be formed with participants with incomplete spinal cord injury. This group will perform 4 weeks of combined explosive strength and specific balance training.

no intervention: Spinal cord injury control group

This group will be formed with participants with incomplete spinal cord injury. They will perform all the evaluation before and after a 4-week period of rest (no training).

no intervention: Healthy control group

Healthy participants will be recruited based on the age and sex of the participants with incomplete spinal cord injury to realize clinical and neurophysiological cortical evaluations.

Interventions

Combined explosive strength and specific balance training group

Training will consist to perform one hour of combined ankle explosive strength training and specific balance training using randomized perturbations.

Explosive strength training: Participants will perform only 2 sets of 3 min (12 contractions for each set) for both lower limbs and both ankle plantar- and dorsiflexion movements.

Balance specific training: Participants will be standing, secured by an adjusted harness, which do not support the weight but is strictly there to prevent a fall. They will have online visual feedback of their CoP via an avatar on the screen in front of them. Each training session will consist of 10 sequences of 3 min, including the 5 different conditions:

Forward tilt of base of support;
Backward tilt of base of support;
Translation forward;
Translation backward;
Without moving their feet, participants will have to move their avatar to reach different targets placed around them on the screen, at different distance from the center.

Primary outcome measure

Change in muscles EMG responses following balance perturbation [ Time Frame: Pre-intervention, immediately after and one-month after intervention ]
Change in center of pressure displacement following balance perturbation using a force platform [ Time Frame: Pre-intervention, immediately after and one-month after intervention ]
Change in ankle muscle strength using force transducer [ Time Frame: Pre-intervention, immediately after and one-month after intervention ]

Central Contacts and Locations

Central contacts

Dorothy Barthélemy, PhD, PT

514-343-7712 dorothy.barthelemy@umontreal.ca

Locations

Neuromobility lab

Recruiting

Montréal, Quebec, Canada

Contacts

Dorothy Barthélemy, PhD, PT

514-343-7712 dorothy.barthelemy@umontreal.ca

More Information

Sponsor

Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

Last update posted

Jan 20, 2022

Last verified

Jan, 2022

Keywords

Combined explosive strength and balance training
Balance control
Corticospinal tract
Intracortical mechanisms
Vestibular system

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal on 2022-01-20.