Recruiting

Home Healthcare

Sponsor:

Massachusetts General Hospital

Code:

NCT05205954

Conditions

Cirrhosis

End Stage Liver DIsease

Liver Cirrhosis

Liver Disease Chronic

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Hepatology Home Hospital

Study Details

Brief summary:

This research study is evaluating a program that entails a healthcare at home intervention for people with advanced liver disease.

Conditions

Cirrhosis

End Stage Liver DIsease

Liver Cirrhosis

Liver Disease Chronic

Study ID

NCT05205954

Start date

Jul 21, 2025

Status verified date

Jul, 2025

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adult patients ≥ 18 years old with diagnosis of cirrhosis based on histology, radiology, and/or elastography presenting to the emergency department or inpatient general medicine service
2. Patients must have one of the following:

1. Ascites (requiring diuretics or serial large volume paracenteses)
2. Hepatic hydrothorax (requiring diuretics)
3. Hepatic encephalopathy (requiring medications)

Exclusion Criteria: All existing MGB home hospital criteria apply, with the following taking precedent for this specific condition

1. History of solid organ transplantation
2. On hemodialysis
3. MELD score > 20
4. Score <10 on Simplified Animal Naming Test (S-ANT1)
5. Current admission for hemodynamically significant GI bleeding or alcohol withdrawal
6. Require routine administration of controlled substances
7. Those deemed ineligible based on the MGH Home Hospital, inpatient medicine or hepatology clinician evaluation

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Hepatology Hospital at Home

Patients with advanced liver disease receive hospital-level care in the home setting

Interventions

Hepatology Home Hospital

The Hepatology Home Hospital intervention entails the following: patient-reported symptoms and vital signs with appropriate triggers for phone calls and home visits, and regular communication with hepatology clinicians regarding care delivered at home to ensure continuity of care.

Primary outcome measure

  • Escalation Rate [ Time Frame: 18 months ]

Central Contacts and Locations

Central contacts

William Munroe, BA

wlmunroe@mgh.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Principal Investigator:

Nneka Ufere, MD, MSCE

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Jul 24, 2025

Last verified

Jul, 2025

Keywords

  • Hospital at home
  • Home hospital

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2025-07-24.