Recruiting

Perturbation Training

Sponsor:

Georgia State University

Code:

NCT05205980

Conditions

Alzheimer Disease

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Interventions

Perturbation training

Study Details

Brief summary:

This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.

Conditions

Alzheimer Disease

Study ID

NCT05205980

Start date

Apr 28, 2023

Status verified date

Feb, 2026

Completion date

Oct 30, 2026

Anticipated

Primary completion date

Oct 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participants must be at least 65 years old;
  • Participants have a clinical diagnosis of probable AD;
  • Participants can read and understand English;
  • Participants must be able to walk independently at least 25 feet;
  • Participants must be able to stand independently for at least 30 seconds;
  • Participants must have a Montreal Cognitive Assessment score of 11-21 or Mini Mental Status Examination score between 18 and 23.

Exclusion Criteria:

  • Individuals have ever experienced perturbation training;
  • Individuals have hypotension or uncontrolled hypertension;
  • Individuals exhibit osteoporosis;
  • Participants suffer from coexisting psychiatric disorders, or other neurological conditions, or injuries, etc.

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Training group

This arm will receive a single-session perturbation training treatment on a treadmill under the protection of a safety harness.

sham comparator: Control group

This arm will not receive perturbation training but will go through harnessed walking on the same treadmill for the same time as the other group.

Interventions

Perturbation training

Participants will experience repeated perturbations mixed with non-perturbed trials on the treadmill with the protection by a harness.

Primary outcome measure

  • Lab-induced faller rate [ Time Frame: 6 months ]

Central Contacts and Locations

Central contacts

Feng Yang, PhD

404-413-8357fyang@gsu.edu

Locations

Reminiscent

Recruiting

Valdosta, Georgia, United States, 31602

Contacts

Debra Tann, Ed.D.

229-415-3333

More Information

Sponsor

Georgia State University

Last update posted

Feb 4, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Georgia State University on 2026-02-04.