Recruiting

POCUS

Sponsor:

Olive View-UCLA Education & Research Institute

Code:

NCT05228717

Conditions

Lung Injury

ARDS

Acute Cardiac Event

Covid19

Ultrasound

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Point of Care Ultrasound

Study Details

Brief summary:

This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of patient with COVID-19. Primary aims include the development of ARDS, refractory hypoxemia, acute cardiac injury, pulmonary embolism, pneumothorax or death. Secondary aims include potential change in CT and plain film utilization given the use of POCUS, as well as emergency department and inpatient LOS (length of stay).

Conditions

Lung Injury

ARDS

Acute Cardiac Event

Covid19

Ultrasound

Study ID

NCT05228717

Start date

Nov 10, 2020

Status verified date

Apr, 2022

Completion date

Jun, 2022

Anticipated

Primary completion date

Jun, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with confirmed COVID-19 pneumonia as the primary diagnosis, or COVID- associated acute hypoxemic respiratory failure or hypoxia (minimum O2 requirement 3L), that are being admitted from the emergency department, who either have waiver of consent, give verbal consent to participate, or have next of kin give consent for participation.

Exclusion Criteria:

  • age < 18 years old, pregnant patients, or patients that verbally refuse participation

Study Design

Enrollment

240 participants

Anticipated

Interventions and Outcome Measures

Arms

COVID+

Patients with confirmed COVID-19 pneumonia as the primary diagnosis, or COVID-associated acute hypoxemic respiratory failure or hypoxia (minimum O2 requirement 3L), that are being admitted from the emergency department, who either have waiver of consent, give verbal consent to participate, or have NOK (next of kin) provide consent.

Exclusion criteria: age <18 years old, pregnant patients, or patients that verbally refuse participation Intervention/observation: q48-72h POCUS of the lungs, heart, and IVC

Interventions

Point of Care Ultrasound

q48-72h point of care ultrasound of the lungs, heart, and IVC (inferior vena cava)

Primary outcome measure

  • Association of POCUS changes with major clinical events [ Time Frame: From admission to 21 days, or endpoint reached ]
  • Time from POCUS worsening to clinical diagnosis. [ Time Frame: From admission to 21 days, or endpoint reached ]

Central Contacts and Locations

Central contacts

James Murphy, MD

7472103107jjmurphy@mednet.ucla.edu

Alan Chiem, MD

7472103107achiem@mednet.ucla.edu

Locations

UCLA-Ronald Reagan

Recruiting

Los Angeles, California, United States, 90095

Contacts

James Murphy, MD

310-794-0785jjmurphy@mednet.ucla.edu

George Lim, MD

3107940785gwlim@mednet.ucla.edu

Olive View-UCLA

Recruiting

Sylmar, California, United States, 91342

Contacts

Alan Chiem, MD MPH

747-210-3107achiem@mednet.ucla.edu

SUNY Downstate

Recruiting

New York, New York, United States, 11203

Contacts

Ian DeSouza, MD

ian.desouza@downstate.edu

Temple University

Recruiting

Philadelphia, Pennsylvania, United States, 19140

Contacts

Ryan Gibbons, MD

ryan.gibbons@tuhs.temple.edu

More Information

Sponsor

Olive View-UCLA Education & Research Institute

Last update posted

Apr 29, 2022

Last verified

Apr, 2022

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-19. This information was provided to ClinicalTrials.gov by Olive View-UCLA Education & Research Institute on 2022-04-29.