Recruiting

Radiation Therapy

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT05233904

Conditions

Advanced Cancer Requiring Palliative Radiation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Diagnostic-CT-enabled Planning

Standard of Care

Study Details

Brief summary:

The objective of this trial is to assess the efficacy, acceptability, and scalability of diagnostic-CT-enabled planning, compared to conventional CT simulation planning.

Conditions

Advanced Cancer Requiring Palliative Radiation

Study ID

NCT05233904

Start date

Jun 8, 2022

Status verified date

Jun, 2022

Completion date

Aug 1, 2023

Anticipated

Primary completion date

Jun 1, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Able to provide informed consent
  • Patient has consented to PRT to bone/soft tissue metastases or primary targets in the thorax, abdomen, or pelvis and RO will use simple planning techniques (i.e. parallel-opposed pair or direct field beam arrangement)
  • Patient will be scheduled for same-day simulation and treatment (if randomized to Arm 1)
  • Patient has a pre-existing and recent (i.e. within 4 weeks of time of enrollment) diagnostic CT or CT-fused scan with full visualization of the region-of-interest which has been acquired from an approved diagnostic scanner
  • Patient positioning scan is deemed acceptable and reproducible (e.g., patient is lying supine and relatively flat, there is no/minimal motion blur, ect.)
  • Intravenous (IV)/oral contrast in the region-of-interest is permitted as long as it does not create artifact which obscured the target volume (density override calculations may be required)

Exclusion Criteria:

  • Any contraindication to receiving radiation
  • Oncologic emergencies and/or on-call cases
  • Pregnant or lactating women
  • Cases requiring composite dosimetric planning to account for previous radiotherapy or extended distance set-up

Study Design

Enrollment

33 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Standard of Care

Patients will be booked for CT simulation and treatment as per the local institution's standard practice.

experimental: Experimental Treatment Workflow

Patients do not require a CT simulation appointment. A radiation treatment appointment will be scheduled on an optical surface guidance-equipped treatment unit as soon as available, but a minimum of 24 hours is required between EBAF processing and fraction 1.

Interventions

Diagnostic-CT-enabled Planning

Diagnostic-CT-enabled planning for patient receiving palliative radiation treatment to bone, soft tissue and lung disease

Standard of Care

Patients will be booked for CT simulation and treatment as per the local institution's standard practice

Primary outcome measure

  • Time in Centre (TIC) on Treatment Day [ Time Frame: 1 Treatment Day ]

Central Contacts and Locations

Central contacts

David Palma, MD

519-685-8500David.Palma@lhsc.on.ca

Melissa O'Neil

Melissa.ONeil@lhsc.on.ca

Locations

London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5W9

Contacts

David Palma, MD

519-685-8500David.Palma@lhsc.on.ca

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Jun 13, 2022

Last verified

Jun, 2022

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2022-06-13.