Recruiting

Secretin

Sponsor:

UCLA

Code:

NCT05235867

Conditions

Anorexia in Adolescence

Eligibility Criteria

Sex: All

Age: 13 - 24

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Conditions

Anorexia in Adolescence

Study ID

NCT05235867

Start date

Feb 1, 2022

Status verified date

Feb, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 13 - 24

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Group 1:

  • male and female patients
  • age 13-24 years
  • diagnosis of restrictive-type anorexia nervosa
  • hospitalization for nutritional support
  • >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
  • Group 2:

  • male and female patients
  • age 13-24 years
  • diagnosis of restrictive-type anorexia nervosa
  • hospitalization for nutritional support
  • <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Exclusion Criteria:

  • 5150 hold
  • Anti-depressant, anti-psychotic, or anticonvulsant medications
  • Previous hospitalization within the past 6 months
  • Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
  • Pregnancy
  • NG or G-tube feeds after day 2 of hospitalization
  • > 10% of nutritional needs from supplemental feeds

Study Design

Enrollment

10 participants

Anticipated

Interventions and Outcome Measures

Arms

dumpers

  • male and female patients
  • age 13-24 years
  • diagnosis of restrictive-type anorexia nervosa
  • hospitalization for nutritional support
  • >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)

non-dumpers

  • male and female patients
  • age 13-24 years
  • diagnosis of restrictive-type anorexia nervosa
  • hospitalization for nutritional support
  • <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Primary outcome measure

  • Change in secretin [ Time Frame: 1 hour ]

Central Contacts and Locations

Central contacts

Misciel Macaraig

310-825-0922mbmacaraig@mednet.ucla.edu

Locations

University of California, Los Angeles (UCLA)

Recruiting

Los Angeles, California, United States, 90095

Contacts

Finnegan Mercer

310-206-7631fjmercer@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Feb 12, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-02-12.