Recruiting

Metabolic Profile

Sponsor:

Texas A&M University

Code:

NCT05240885

Conditions

Aging

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Interventions

Stable tracer infusion in a postabsorptive state

Study Details

Brief summary:

Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.

Conditions

Aging

Study ID

NCT05240885

Start date

Mar 4, 2022

Status verified date

Sep, 2025

Completion date

Sep, 2026

Anticipated

Primary completion date

Sep, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Stable body-weight (± 5%) for the past 3 months
  • Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
  • Ability to walk, sit down and stand up independently or with walking mobility aids
  • Ability to lie in a supine or elevated position for up to 3 hours
  • Willingness and ability to comply with the protocol

Exclusion Criteria:

  • Insulin dependent diabetes mellitus
  • Established diagnosis of malignancy
  • History of untreated metabolic diseases including hepatic or renal disorder
  • Presence of acute illness or metabolically unstable chronic illness
  • Presence of fever within the last 3 days
  • Use of short course of oral corticosteroids within 4 weeks preceding study day
  • Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
  • (Possible) pregnancy
  • Already enrolled in another clinical trial and that clinical trial interferes with participating in this study

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Controls

Study subjects that are eligible based on inclusion/exclusion criteria

Screening visit: body weight and composition by DXA, height, and vital signs will be assessed.

Study day(s): may include combinations of stable tracer infusions and with blood draws, cognitive and muscle performance testing

Interventions

Stable tracer infusion in a postabsorptive state

Multiple stable-labeled tracers of amino acids, ketoacids, glycerol, short-chain fatty acids

Primary outcome measure

  • Age-related changes in whole-body protein and amino acid metabolism [ Time Frame: 2 hours ]

Central Contacts and Locations

Central contacts

Laura Ruebush, PhD

979-422-1789le.ruebush@ctral.org

Marielle Engelen, PhD

979-422-1789mpkj.engelen@ctral.org

Locations

Human Clinical Research Building

Recruiting

College Station, Texas, United States, 77845

Contacts

Laura Ruebush, PhD

le.ruebush@ctral.org

More Information

Sponsor

Texas A&M University

Last update posted

Oct 2, 2025

Last verified

Sep, 2025

Keywords

  • stable isotopes
  • disease
  • metabolism

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Texas A&M University on 2025-10-02.