Recruiting

Young Lung

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT05265429

Conditions

Non Small Cell Lung Cancer

Small Cell Lung Carcinoma

NUT Carcinoma

Eligibility Criteria

Sex: All

Age: 15+

Healthy Volunteers: Not accepted

Interventions

Data and Specimen Collection

Study Details

Brief summary:

The purpose of this research study is to learn more about lung cancer (NSCLC or SCLC) diagnosed in adults at ages 45 or younger.

Conditions

Non Small Cell Lung Cancer

Small Cell Lung Carcinoma

NUT Carcinoma

Study ID

NCT05265429

Start date

Jan 1, 2023

Status verified date

Oct, 2025

Completion date

Aug 1, 2027

Anticipated

Primary completion date

Aug 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 15+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 45 and under at lung cancer diagnosis
  • Pathologically confirmed bronchogenic lung carcinoma (NSCLC or SCLC of any stage) at any treatment time point
  • Provision of written informed consent
  • Willingness to undergo no more than two (2) peripheral blood draws in a four (4) week period, with no more than 50 ml peripheral blood collected over eight (8) weeks
  • Individuals under age 18 are eligible for study if they meet defined criteria; in addition, consent for participation must be given by a legal guardian or parent

Exclusion Criteria:

  • Individuals who decline to sign consent
  • Individuals who are unable to give consent or assent and are without a designated healthcare proxy
  • Compromise of patient diagnosis or staging if tissue is used for research

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Data/Biospecimen Collection

Tumor and saliva specimens from participants with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) diagnosed at age 45 or younger

Interventions

Data and Specimen Collection

  • Provide research team access to relevant medical records
  • Answer two (2) short questionnaires at time of consent
  • Provide up to 5 tubes (37 ml) of blood at or near the time of consent, and/or saliva sample
  • Consider consenting to other optional parts of the research such as:

  • Providing additional blood or tissue samples in the future (optional)
  • Providing permission for obtainment of stored tissue specimens from lung cancer surgeries or biopsies from the pathology departments where they have been stored (optional)

Primary outcome measure

  • Repository of specimens and data [ Time Frame: 5 years or study closure ]

Central Contacts and Locations

Central contacts

Pasi A Janne, MD, PhD

617-632-6036Pasi_Janne@dfci.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Jessica Line, MD

617-724-1134jjlin1@partners.org

Principal Investigator:

Jessica Lin, MD

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Pasi A Janne, MD, PhD

617-632-6036Pasi_Janne@dfci.harvard.edu

Principal Investigator:

Pasi A Janne, MD, PhD

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Oct 29, 2025

Last verified

Oct, 2025

Keywords

  • Non Small Cell Lung Cancer
  • Small Cell Lung Carcinoma
  • Genetics
  • Genomics
  • Young lung cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2025-10-29.