Recruiting

Observational Study

Sponsor:

University of Minnesota

Code:

NCT05269472

Conditions

Trigeminal Neuralgia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Trigeminal Electrophysiology

Study Details

Brief summary:

The study intervention is to perform standard somatosensory evoked responses limited to the face during rhizotomy procedures of the gasserian ganglion (trigeminal ganglion) for the treatment of trigeminal neuralgia. The evoked responses will be measured at two locations before and after the clinical rhizotomy including: the standard contralateral scalp (EEG) and at the gasserian ganglion through an FDA-approved recording electrode.

Conditions

Trigeminal Neuralgia

Study ID

NCT05269472

Start date

Apr 4, 2022

Status verified date

Nov, 2025

Completion date

Apr 7, 2027

Anticipated

Primary completion date

Apr 7, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria (TGN):

  • Adults of 18 years or older
  • Scheduled to undergo percutaneous rhizotomy for facial pain

Exclusion Criteria (TGN):

  • Facial pain of unclear origin (i.e. not clearly TGN pain)
  • Rhizotomy procedure canceled

Inclusion Criteria (Healthy controls)

  • Adults of 18 years or older

Exclusion Criteria (Healthy Controls)

  • Diagnosis or history of facial pain such as TMD or TGN
  • History of migraine
  • History of any functional pain disorder: fibromyalgia, IBS, CRPS
  • Recent chronic pain (within last month)
  • Unwilling to participate for two hours in lab
  • Current acute pain

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Arms

Trigeminal Electrophysiology

Controls

Interventions

Trigeminal Electrophysiology

This study will pilot and test the feasibility of introducing electrophysiology into the routine rhizotomy procedure by including trigeminal somatosensory evoked potentials (TSEPs) and recording from electrodes at the level of the ganglion.

Primary outcome measure

  • Determine the feasibility of measuring trigeminal somatosensory evoked potentials to improve personalized mapping during percutaneous rhizotomy [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Matthew Maple

612-946-1424maple036@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Matthew Maple

612-946-1424maple036@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Nov 19, 2025

Last verified

Nov, 2025

Keywords

  • Trigeminal Neuralgia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2025-11-19.