Recruiting

Dextromethorphan

Sponsor:

Nathanael Heckmann

Code:

NCT05278494

Conditions

Post-operative Pain

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Dextromethorphan Hydrobromide

Placebo

Study Details

Brief summary:

A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain

Conditions

Post-operative Pain

Study ID

NCT05278494

Start date

Sep 15, 2022

Status verified date

Mar, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Main Inclusion Criteria:

  • Patients Age ≥18 planning to undergo total knee arthroplasty
  • ASA classes I - III

Main Exclusion Criteria:

  • BMI ≥ 35
  • History opioid abuse
  • History of intractable vomiting after previous surgery

Study Design

Enrollment

160 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Dextromethorphan

placebo comparator: Placebo

Interventions

Dextromethorphan Hydrobromide

PO

Placebo

PO

Primary outcome measure

  • Post-op opioid use [ Time Frame: 24 hours ]

Central Contacts and Locations

Central contacts

Pui Yan, MS

323-442-6984puiyan@med.usc.edu

Locations

Keck School of Medicine of USC

Recruiting

Los Angeles, California, United States, 90033

Contacts

Pui Yan, MS

puiyan@med.usc.edu

More Information

Sponsor

Nathanael Heckmann

Last update posted

Mar 27, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Nathanael Heckmann on 2026-03-27.