Recruiting

Optogenetics

Sponsor:

Institute of Molecular and Clinical Ophthalmology Basel

Code:

NCT05294978

Conditions

Retinal Dystrophies

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Interventions

Optical coherence tomography (OCT)

Study Details

Brief summary:

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Conditions

Retinal Dystrophies

Study ID

NCT05294978

Start date

Jul 1, 2021

Status verified date

Jul, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria (patients):

  • Diagnosis of generalized IRD
  • Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
  • Availability of macular optical coherence tomography (OCT)

Inclusion Criteria (controls):

  • Normal ophthalmic findings
  • Availability of macular optical coherence tomography (OCT)

Exclusion Criteria (all):

  • Other eye diseases with a significant effect on vision or retinal structure
  • Extraocular disease affecting retinal structure such as neurodegenerative diseases

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients

-Availability of macular optical coherence tomography (OCT)

Controls

-Availability of macular optical coherence tomography (OCT)

Interventions

Optical coherence tomography (OCT)

Data of macular optical coherence tomography (OCT)

Primary outcome measure

  • OCT - Central retinal volume [ Time Frame: Baseline (about 10 minutes) ]

Central Contacts and Locations

Central contacts

Lucas Janeschitz-Kriegl, MD

+41787494373lucas.janeschitz@iob.ch

Tiana Koottungal

+41788486737tiana.koottungal@iob.ch

Locations

University of California San Francisco, Department of Ophthalmology

Recruiting

San Francisco, California, United States, 94158

Principal Investigator:

Jacque Duncan, MD

Bascom Palmer Eye Institute

Recruiting

Miami, Florida, United States, 33136

Principal Investigator:

Byron L Lam, MD

University of Pittsburgh, Department of Ophthalmology

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Principal Investigator:

Jose A Sahel, MD

More Information

Sponsor

Institute of Molecular and Clinical Ophthalmology Basel

Last update posted

Jul 31, 2025

Last verified

Jul, 2025

Keywords

  • Cone-Optogenetics
  • Rod-cone Dystrophy
  • Cone-rod Dystrophy
  • Generalized retinal dystrophies
  • Inherited retinal disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Institute of Molecular and Clinical Ophthalmology Basel on 2025-07-31.