Recruiting

NeuPaRT

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT05306327

Conditions

Determination of Death

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

electroencephalography (EEG)

Study Details

Brief summary:

The purpose of this study is to determine when brain function stops compared to when the heart stops by monitoring electrical brain activity in patients who are taken off life support and progress to death in the intensive care unit.

Conditions

Determination of Death

Study ID

NCT05306327

Start date

Oct 18, 2022

Status verified date

Jan, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age ≥ 18 years
2. Plan for the withdrawal of life sustaining measures (WLSM)
3. Attending physician anticipates patient will die within 24 hours of the withdrawal of life sustaining measures
4. Patient has an indwelling arterial cannula for monitoring blood pressure

Exclusion Criteria:

1. Brain death or plan for Neurologic Determination of Death (NDD)
2. Injuries that anatomically preclude the use of neurologic monitoring

Study Design

Enrollment

158 participants

Anticipated

Interventions and Outcome Measures

Interventions

electroencephalography (EEG)

1. brain cortical activity using full scalp
2. cerebral blood flow velocity
3. during the dying process following planned withdrawal of life sustaining measures (WLSM)

Primary outcome measure

  • Patient Accrual complete study procedures) [ Time Frame: 2022 to 2023 ]

Central Contacts and Locations

Central contacts

Teneille Gofton

519-663-2911teneille.gofton@lhsc.on.ca

Marat Slessarev

519-685-8500marat.slessarev@lhsc.on.ca

Locations

University of Calgary Foothills Campus

Recruiting

Calgary, Alberta, Canada, T2N1N4

Kingston Health Sciences Centre

Recruiting

Kingston, Ontario, Canada, K7L2V7

London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5A5

Contacts

Teneille Gofton

519-685-8500teneille.gofton@lhsc.on.ca

Marat Slessarev

519-685-8500marat.slessarev@lhsc.on.ca

Ottawa Hospital

Recruiting

Ottawa, Ontario, Canada, K1H8L6

Centre hospitalier de l'Université de Montréal,

Recruiting

Montreal, Quebec, Canada, H2X3E4

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Jan 30, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2026-01-30.