Recruiting

Cancer Research

Sponsor:

Mayo Clinic

Code:

NCT05324553

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Tissue Collection

Blood Collection

Buccal Swab

Study Details

Brief summary:

Study goal is to collect tumor specimens that may inform cancer biology to eventually improve outcomes for patients with cancer. This proposal represents a highly collaborative effort to support cancer research with the goal of developing novel therapeutic strategies using patient derived preclinical models.

This study is being done to collect samples of tumor tissues, matched normal tissue when possible, and approximately 50 mL of blood.

Conditions

Cancer

Study ID

NCT05324553

Start date

Apr 6, 2022

Status verified date

Jun, 2026

Completion date

Mar 31, 2028

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18 years of age and older
  • Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue

Exclusion Criteria:

  • Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent
  • Institutionalized or incarcerated patients
  • Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use
  • Biopsy must not be considered more than minimal risk to the patient.
  • Have a contraindication to percutaneous biopsy including:

1. Significant coagulopathy that cannot be adequately corrected.
2. Severely compromised cardiopulmonary function or hemodynamic instability.
3. Lack of a safe pathway to the lesion per the interventional radiologist.
4. Inability of the patient to cooperate with, or to be positioned for, the procedure.

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Tissue Collection

Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.

Blood Collection

Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional testing

Buccal Swab

Buccal swab may be requested, if necessary, to generate germline data.

Interventions

Tissue Collection

Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.

Blood Collection

Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional

Buccal Swab

Buccal swab may be requested, if necessary, to generate germline data.

Primary outcome measure

  • Number of participants accrued with genomic, microbiome, and drug sensitivity components of aggressive cancer. [ Time Frame: Up to 6 years post tissue and blood collection ]

Central Contacts and Locations

Central contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Tanya M. Schnick

507 293-7582Schnick.Tanya@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

Aaron S. Mansfield, M.D.

More Information

Sponsor

Mayo Clinic

Last update posted

Jun 9, 2026

Last verified

Jun, 2026

Keywords

  • Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-06-09.