Recruiting

Observational Study

Sponsor:

Marquette University

Code:

NCT05344001

Conditions

Aging

Athletic Injuries

Physical Inactivity

Knee Injuries and Disorders

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Accepted

Study Details

Brief summary:

Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.

Conditions

Aging

Athletic Injuries

Physical Inactivity

Knee Injuries and Disorders

Study ID

NCT05344001

Start date

Apr 18, 2022

Status verified date

Feb, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Accepted

Please see cohorts for specific inclusion/exclusion criteria

Inclusion Criteria:

  • Age 18-25 years OR age 40-64 years
  • Current or former collegiate varsity athlete OR non-athlete control

Exclusion Criteria:

  • Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
  • Pregnancy
  • Lower extremity joint replacement (e.g., hip or knee replacement)

Study Design

Enrollment

450 participants

Anticipated

Interventions and Outcome Measures

Arms

Midlife former athletes with a prior knee injury

Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season; history of at least 1 prior traumatic knee injury including but not limited to ACL or PCL rupture and/or reconstruction, medial and/or lateral meniscus tear or surgery, osteochondral defect, and/or intra-articular (i.e., tibiofemoral or patellofemoral) fracture.

Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).

Midlife former athletes without a prior major lower extremity injury

Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., football, baseball, basketball, field hockey, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season.

Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).

Midlife controls

Inclusion Criteria: Age 40-64 years.

Exclusion Criteria: Prior participation in a collegiate varsity sport or professional sport; neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).

Young adult athletes

Inclusion Criteria: Age 18-25 years. Participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the varsity collegiate level.

Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).

Young adult controls

Inclusion Criteria: Age 18-25 years.

Exclusion Criteria: Prior or current participation in any collegiate varsity sport; prior major lower extremity injury or surgery (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation); current participation in competitive sport (e.g., collegiate club sport) more than 3x/week; joint replacement in the lower extremity (i.e., knee or hip replacement); current pregnancy; or neurologic condition (e.g., stroke, Parkinson's) and/or degenerative condition that impairs function.

Primary outcome measure

  • 30-Second Chair Stand Test (primary outcome for Aim 1) [ Time Frame: Baseline ]
  • Sedentary Behavior (primary outcome for Aim 2) [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Jacob J. Capin, DPT, PhD, MS

414-288-7865jacob.capin@marquette.edu

Locations

Marquette University

Recruiting

Milwaukee, Wisconsin, United States, 53233

Contacts

Jacob J. Capin, PhD, DPT, MS

4142887865jacob.capin@marquette.edu

More Information

Sponsor

Marquette University

Last update posted

Feb 25, 2026

Last verified

Feb, 2026

Keywords

  • Sports Medicine
  • Injury
  • Athlete
  • Sport
  • Physical Activity
  • Function
  • Health
  • Knee

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-08. This information was provided to ClinicalTrials.gov by Marquette University on 2026-02-25. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.