Recruiting

Exercise TrainingExercise Training and Fat Metabolism in Postmenopausal Women

Sponsor:

Florida State University

Code:

NCT05351476

Conditions

Postmenopausal Symptoms

Obesity

Prediabetic State

Eligibility Criteria

Sex: Female

Age: 50 - 70+

Healthy Volunteers: Not accepted

Interventions

Resistance Exercise

Endurance Exercise

Study Details

Brief summary:

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Conditions

Postmenopausal Symptoms

Obesity

Prediabetic State

Study ID

NCT05351476

Start date

May 20, 2022

Status verified date

Apr, 2026

Completion date

Apr 30, 2027

Anticipated

Primary completion date

Apr 30, 2027

Anticipated

Eligibility Criteria

Sex: Female

Age: 50 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Women
Postmenopausal (50-75 yrs.)
Obese (BMI 30-50 kg/m2)
Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
Non-smokers
No hormone replacement therapy for at least the past two years.

Exclusion Criteria:

Engaging in purposeful resistance training or endurance training (> 20min/day, > 2 days/week)
Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
Type 1 or type 2 diabetes
Medical problems in which exercise is contraindicated, such as chronic infections
History of, or currently presentation with, cancer, cardiovascular or respiratory disease
Uncontrolled thyroid dysfunction, liver or renal dysfunction
Taking any medication affecting lipid metabolism
Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
Smokers and those with diagnosed eating disorders

Study Design

Enrollment

120 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Resistance Exercise

Participants do regular resistance exercise for 12 weeks.

experimental: Endurance Exercise

Participants do regular endurance exercise for 12 weeks.

Interventions

Resistance Exercise

200 Kcal worth of weightlifting, 3 times/week for 12 weeks

Endurance Exercise

200 Kcal worth of treadmill walking, 3 times/week for 12 weeks

Primary outcome measure

Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks [ Time Frame: 12 weeks of resistance or endurance training ]
Change from baseline gluteal adipose tissue glycerol concentration at 12 weeks [ Time Frame: 12 weeks of resistance or endurance training ]
Change from baseline whole-body lipolysis at 12 weeks [ Time Frame: 12 weeks of resistance or endurance training ]

Central Contacts and Locations

Central contacts

Robert C Hickner, PhD

850-644-1375 rhickner@fsu.edu

Michael J Ormsbee, PhD

850-644-2194 mormsbee@fsu.edu

Locations

Florida State University

Recruiting

Tallahassee, Florida, United States, 32306

Principal Investigator:

Michael J Ormsbee, PhD

More Information

Sponsor

Florida State University

Last update posted

Apr 13, 2026

Last verified

Apr, 2026

Keywords

Resistance Exercise
Fat Metabolism
Postmenopause

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Florida State University on 2026-04-13.