Recruiting

Spinal Cord Stimulation

Sponsor:

UCLA

Code:

NCT05356286

Conditions

Cervical Stenosis

Disk, Herniated

Spondylosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

epidural electrical stimulation

Study Details

Brief summary:

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.

Conditions

Cervical Stenosis

Disk, Herniated

Spondylosis

Study ID

NCT05356286

Start date

Jan 21, 2011

Status verified date

Mar, 2025

Completion date

Jan 22, 2027

Anticipated

Primary completion date

Jan 22, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized.

Exclusion Criteria:

  • none

Study Design

Enrollment

150 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Electrical Stimulation group

Epidural Electrical Stimulation of the Cervical Spinal Cord

Interventions

epidural electrical stimulation

Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.

Primary outcome measure

  • Change in respiratory frequency [ Time Frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation ]
  • Change in respiratory tidal volume [ Time Frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation ]

Central Contacts and Locations

Central contacts

Daniel Lu, MD

310/825/4321dclu@mednet.ucla.edu

Locations

University of California, Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Daniel Lu, MD

310-825-4321dclu@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Mar 10, 2025

Last verified

Mar, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2025-03-10.