Recruiting

Engage

Sponsor:

University of Nevada, Las Vegas

Code:

NCT05356611

Conditions

Depression in Old Age

Psychotherapy

Mild Cognitive Impairment

Executive Dysfunction

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Interventions

Engage

Study Details

Brief summary:

Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations. Cognitive decline is one such factor that places significant burden on older adults and can interfere with traditional mental health therapies. Engage is a behavioral treatment approach that has shown to be effective in treating late life depression. The investigators are testing the feasibility of Engage as a treatment method for late life depression in older adults with cognitive decline. The objective is to corroborate Engage as an alternative late life depression treatment method for a sub-population of older adults with cognitive decline. Cognitive decline poses a unique mental health treatment barrier that is often over looked in younger populations. With a relatively higher prevalence of cognitive decline in older adulthood, it is imperative that a feasible mental health treatment program that can be effective in the presence of cognitive decline.

Conditions

Depression in Old Age

Psychotherapy

Mild Cognitive Impairment

Executive Dysfunction

Study ID

NCT05356611

Start date

Sep 24, 2023

Status verified date

Aug, 2024

Completion date

May, 2025

Anticipated

Primary completion date

Dec, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 60 or older
  • Ability to read, write, and speak English
  • Located in Las Vegas or surrounding area
  • Ability to travel to UNLV campus by self or possible caregiver for regular study visits
  • Clinically significant symptoms of depression as evidenced by: 1) Scores > 5 on the Geriatric Depression Scale-Short Form (GDS-SF)
  • Mild cognitive impairment as evidenced by: 1) Scores > 18 and < 25 on the Montreal Cognitive Assessment (MoCA)

Exclusion Criteria:

  • Active suicidal ideation
  • History of suicide attempt(s)
  • Current symptoms of: 1) Psychosis; 2) Active substance use disorder
  • Reported history of: 1) Bipolar disorder ("manic depression"); 2) Intellectual disability
  • Currently in or scheduled to initiate individual psychotherapy to avoid treatment interference
  • Psychotropic medication permitted if dose was stable over the past 2 weeks
  • Currently living in an institutional setting (e.g., assisted living, inpatient, skilled nursing)
  • Presence of notable memory-specific cognitive deficits as evidenced by: scores < 9 on the MoCA memory subscale (rendering it difficult to participate in and track/recall events for weekly psychotherapy)

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Engage Treatment

The study is a single-arm study. The single-arm will be implementation of the 9-week protocol of Engage in an older adult population with late-life depression and comorbid executive dysfunction and mild cognitive impairment.

Interventions

Engage

Engage is a 9-week, behavioral-based, psychotherapy treatment protocol for late-life depression.

Primary outcome measure

  • Hamilton Depression Rating Scale [ Time Frame: Assessed at Baseline, Week 6, Week 9, and Week 36 follow-up. ]

Central Contacts and Locations

Central contacts

Brenna R Renn, PhD

7028950596brenna.renn@unlv.edu

Matthew S Schurr, MA

7026957708schurm1@unlv.nevada.edu

Locations

University of Nevada

Recruiting

Las Vegas, Nevada, United States, 89154

Contacts

Brenna R Renn, PhD

702-895-0596brenna.renn@unlv.edu

More Information

Sponsor

University of Nevada, Las Vegas

Last update posted

Aug 6, 2024

Last verified

Aug, 2024

Keywords

  • Older Adults
  • Late-Life Depression

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Nevada, Las Vegas on 2024-08-06.