Recruiting

AF Ablation

Sponsor:

University of Vermont

Code:

NCT05376748

Conditions

Heart Failure With Preserved Ejection Fraction

Atrial Fibrillation

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

In a prospective, observational pilot study of patients scheduled for an atrial fibrillation (AF) ablation at the University of Vermont Medical Center the investigators will compare exercise capacity before and four months after AF ablation.

Conditions

Heart Failure With Preserved Ejection Fraction

Atrial Fibrillation

Study ID

NCT05376748

Start date

Apr 15, 2022

Status verified date

Jun, 2023

Completion date

Dec 30, 2024

Anticipated

Primary completion date

Jun 30, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • H2FpEF score of ≥ 6 (corresponding to >90% probability of HFpEF (19))
  • echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50%
  • at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea).
  • AF ablation scheduled at UVMMC

Exclusion Criteria:

  • Life expectancy <12 months
  • moderate or more valvular disease
  • inability to walk on a treadmill

Study Design

Enrollment

34 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Change in peak VO2 [ Time Frame: before AF ablation and 4 months after AF ablation ]

Central Contacts and Locations

Central contacts

Nicole Habel, MD

8028470000nicole.habel@uvmhealth.org

Amy Henderson

amy.henderson@uvmhealth.org

Locations

University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05405

Contacts

Nicole Habel, MD

nicole.habel@uvmhealth.org

More Information

Sponsor

University of Vermont

Last update posted

Jun 22, 2023

Last verified

Jun, 2023

Keywords

  • Ablation
  • HFpEF
  • atrial fibrillation
  • exercise capacity
  • peak oxygen consumption

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Vermont on 2023-06-22.