Recruiting

Observational Study

Sponsor:

University of Utah

Code:

NCT05392582

Conditions

Chronic Inflammation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation.

The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.

Conditions

Chronic Inflammation

Study ID

NCT05392582

Start date

Nov 12, 2024

Status verified date

Dec, 2025

Completion date

Jan 1, 2028

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Age between 18 - 35y; 65y and older
2. BMI: <30 kg/m2
3. Ability to sign informed consent
4. For older participant group: Clinical Frailty Scale score < 3 and Mini-Cog score > 3
5. Good general medical health, ambulatory and in independent living setting

Exclusion Criteria:

  • History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
  • History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
  • History of kidney disease or failure (CKD > stage 4)
  • History of vascular disease
  • Uncontrolled hypertension - Elevated systolic pressure >150 or a diastolic blood pressure > 100
  • Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
  • Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
  • Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
  • Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
  • History of stroke with motor disability
  • A recent history (<12 months) of GI bleed
  • History of liver disease or AST/ALT 2 times above the normal limit
  • History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
  • Current smokers or current tobacco use
  • Current pregnancy as determined by positive pregnancy test
  • Any staff members who report directly to the principal investigators.

Study Design

Enrollment

40 participants

Anticipated

Interventions and Outcome Measures

Arms

Young

Young healthy adult participants

Older

Older healthy adult participants

Primary outcome measure

  • Inflammation [ Time Frame: Determined in older adults and in younger adults at a single visit (baseline). ]

Central Contacts and Locations

Central contacts

Micah Drummond, PhD

801-213-2737micah.drummond@hsc.utah.edu

Locations

The University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Micah Drummond, PhD

801-213-2737

micah.drummond@hsc.utah.edu

Principal Investigator:

Micah Drummond

More Information

Sponsor

University of Utah

Last update posted

Dec 5, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Utah on 2025-12-05.