Recruiting

Electrical Stimulation

Sponsor:

University of Alberta

Code:

NCT05395715

Conditions

Cubital Tunnel Syndrome

Electrical Stimulation

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Electrical stimulation

Study Details

Brief summary:

Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor. Therefore, alternative adjunct treatments capable of increasing the speed of nerve regeneration are much needed.

Conditions

Cubital Tunnel Syndrome

Electrical Stimulation

Study ID

NCT05395715

Start date

Apr 1, 2022

Status verified date

Feb, 2026

Completion date

Jun 28, 2028

Anticipated

Primary completion date

Mar 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Patients aged >18 yr,
2. If signs and symptoms of severe CuTS (ie, McGowan-Goldberg grade 3) were observed,
3. If needle EMG examination showed evidence of chronic motor axonal loss and reduced recruitment in the ulnar-innervated intrinsic hand muscles, and
4. If electrophysiologic evidence of severe motor axonal loss with motor unit number estimation (MUNE) greater than 2 standard deviations below the normative mean.

Exclusion Criteria:

1\) Patients were excluded if they had concurrent nerve injury, prior surgery for CuTS or coexisting neurologic conditions

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Control

Control patients will receive cubital tunnel surgery and sham stimulation.

experimental: Conditioning electrical stimulation

Patients in the stimulation group will receive surgery as well as 1 hour of 20 Hz electrical stimulation 7 days prior to surgery

Interventions

Electrical stimulation

Patients with cubital tunnel syndrome will receive either surgery and sham stimulation, or conditioning electrical stimulation 7 days prior to surgery

Primary outcome measure

  • Motor unit number estimation [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Ming Chan

(780) 492-1614Ming.Chan@ualberta.ca

Locations

University of Alberta

Recruiting

Edmonton, Alberta, Canada, T6G 2E1

Contacts

Mithun Rajshekar, PhD

7802481896rajsheka@ualberta.ca

More Information

Sponsor

University of Alberta

Last update posted

Feb 9, 2026

Last verified

Feb, 2026

Keywords

  • Cubital tunnel syndrome
  • Nerve regeneration
  • Electrical stimulation
  • Functional outcomes
  • Randomized control trial
  • Surgery
  • Peripheral nerve regeneration

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alberta on 2026-02-09.