CelastrolEffect of Different Ingestion Doses of Celastrol on Human Sperm Motility

Inclusion Criteria:

1. Individuals who are between 18 and 40 years of age and who are found to be healthy without any underlying medical conditions that could affect sperm motility, and are not taking any daily medications. This does not exclude patients who take drugs prn.
2. Individuals who have not be involved in other clinical trials during the last 90 days. -

Exclusion Criteria:

1. Individuals who have been involved in any other clinical trial during the last 90 days.
2. Individuals who have sperm counts lower than that considered "normal." i.e. a sperm count of \~20 million sperm per milliliter of ejaculate, and (b) sperm motility of ≥ 40% one hour after ejaculate.
3. Clinically significant cardiac disease including uncontrolled congestive heart failure and unstable angina
4. Individuals on medications that the clinician feels may affect sperm motility and/or otherwise interfere with the results
5. Medications that might interfere with blood chemistry, or CBCs
6. Subjects who are taking daily medications. The use of therapies prn is allowed.
7. Subjects Less than 18 years of age or over 40 years of age
8. Prisoners
9. Subjects who have taken anabolic steroid or testosterone during the last six months.
10. Subjects with a current history of addictive alcohol or illegal drug abuse (e.g. cocaine, heroin, etc.).

The use of marijuana is allowed, but not preferred.
11. Subjects who are taking 5-alpha-reductase inhibitors (finasteride (Propecia®) and dutasteride (Avodart®), or Chemotherapy: -
12. Smokers