Recruiting

Sentence Production Training

Sponsor:

Purdue University

Code:

NCT05415501

Conditions

Aphasia

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Interventions

Sentence training

Study Details

Brief summary:

This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.

Conditions

Aphasia

Study ID

NCT05415501

Start date

Aug 1, 2021

Status verified date

Dec, 2024

Completion date

May 30, 2026

Anticipated

Primary completion date

May 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Individuals with post-stroke aphasia
  • At least 6 months post-onset of eft hemisphere stroke
  • Native speaker of English
  • Normal or corrected to normal hearing and vision
  • High-school educated
  • Difficulty communicating in sentences, with some ability to use words independently

Exclusion Criteria:

  • Severe apraxia of speech
  • Other neurological conditions affecting communication (e.g., dementia)
  • Uncontrolled psychiatric/psychological conditions affecting thinking and communication
  • Active alcohol/substance abuse

Study Design

Enrollment

104 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Structural priming training

Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each session. In experiment 4, participants will receive a structural priming treatment in a single-subject design.

Interventions

Sentence training

Participants will be trained to read, make, and recall sentences during each session.

Primary outcome measure

  • Production of target sentences on action description pictures [ Time Frame: From baseline up to 1-week post training or 2-month post treatment ]
  • Comprehension of target sentences in a sentence-to-picture matching task [ Time Frame: From baseline up to 1-week post training or 2-month post treatment ]
  • Real-time comprehension of target sentences in a sentence-to-picture matching task [ Time Frame: From baseline up to 1-week post training or 2-month post treatment ]

Central Contacts and Locations

Central contacts

Jiyeon Lee, PhD

7654943810lee1704@purdue.edu

Jiyeon Lee

7654943810lee1704@purdue.edu

Locations

Purdue University

Recruiting

West Lafayette, Indiana, United States, 47907

Contacts

Jiyeon Lee

765-494-3810lee1704@purdue.edu

More Information

Sponsor

Purdue University

Last update posted

Dec 18, 2024

Last verified

Dec, 2024

Keywords

  • aphasia training
  • aphasia treatment
  • sentences
  • grammar

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Purdue University on 2024-12-18.