Recruiting

Extracellular Vesicles

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT05424029

Conditions

Non-Small Cell Lung Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to find out if fluid rinsed from peoples' airways (bronchial washing samples) during routine surgery to remove (resect) their non-small cell lung cancer (NSCLC) tumors contains enough vesicles to do testing that may help the researchers learn more about their NSCLC.

Conditions

Non-Small Cell Lung Cancer

Study ID

NCT05424029

Start date

Jun 14, 2022

Status verified date

Jul, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible.
  • Patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis.

Exclusion Criteria:

  • Patients with active infection or pneumonia which may impact exosome makeup
  • Additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • to isolate exosomes from bronchial washings [ Time Frame: day 1 ]

Central Contacts and Locations

Central contacts

David Jones, MD

212-639-6428jonesd2@mskcc.org

Yuan Liu, MD, PhD

646-888-3640

Locations

Memorial Sloan Kettering Basking Ridge (Consent Only)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Monmouth (Consent Only)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Bergen (Consent Only)

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Suffolk - Commack (Consent Only)

Recruiting

Commack, New York, United States, 11725

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Westchester (Consent Only)

Recruiting

Harrison, New York, United States, 10604

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

David Jones, MD

212-639-6428

Yuan Liu, MD, PhD

646-888-3640

Principal Investigator:

David Jones, PhD

Memorial Sloan Kettering Nassau (Consent Only)

Recruiting

Uniondale, New York, United States, 11553

Contacts

David Jones, MD

212-639-6428

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Jul 7, 2026

Last verified

Jul, 2026

Keywords

  • Extracellular Vesicles and Particles
  • Biomarkers
  • 22-155

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-07-07.