Recruiting

Tele-Rehabilitation

Sponsor:

VA Office of Research and Development

Code:

NCT05425264

Conditions

Post SARS-CoV2 (COVID-19)

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Tele-exercise

Study Details

Brief summary:

The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery. This award will investigate the effect of a novel, home-based, supervised, group exercise tele-rehabilitation in Veterans recovered from COVID-19 on cardiopulmonary and physical function.

Conditions

Post SARS-CoV2 (COVID-19)

Study ID

NCT05425264

Start date

Jun 29, 2023

Status verified date

Nov, 2025

Completion date

Jan 30, 2028

Anticipated

Primary completion date

Jan 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Veteran
  • documented COVID-19 > 90 days ago
  • diagnosis of 2 of following conditions: hypertension, diabetes, cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease OR 1 condition and BMI > 30 kg/m2

Exclusion Criteria:

  • myocardial infarction (within 3 months)
  • exertional or unstable angina (chest pain that limits activity)
  • severe congestive heart failure (EF < 20% in last year or NYHA Classification III or IV)
  • uncontrolled hypertension (SBP >180 \&/or DBP > 110 mm Hg at screening)
  • screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code)
  • poorly controlled diabetes mellitus (FBS>200 mg/dl, RBS > 299 mg/dl, or HbA1C > 10)
  • treatment for cancer except skin cancer (within 3 months)
  • peripheral vascular disease with claudication
  • severe arthritis limiting ambulation
  • neurologic disease limiting ambulation (weakness requiring assist device; severe neuropathy)
  • end stage liver disease (decompensated liver disease)
  • End stage renal failure (dialysis)
  • severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month)
  • high fall risk (history of falls, bone fracture)
  • dementia (based on Evaluation to Consent)
  • signs or symptoms of any medical comorbidity that would preclude exercise testing or training
  • exercises on routine basis (structured aerobic exercise > 3 time per week)

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Tele-exercise

Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.

Interventions

Tele-exercise

Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.

Primary outcome measure

  • Change in VO2peak [ Time Frame: Baseline and after 12 weeks tele-exercise ]

Central Contacts and Locations

Central contacts

Alice S Ryan, PhD

(410) 605-7851Alice.Ryan@va.gov

Locations

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Recruiting

Baltimore, Maryland, United States, 21201

Contacts

Kristina Marcus, MS

(410) 605-7000kristina.marcus@va.gov

Principal Investigator:

Alice S. Ryan, PhD

More Information

Sponsor

VA Office of Research and Development

Last update posted

Nov 10, 2025

Last verified

Nov, 2025

Keywords

  • Exercise
  • COVID-19
  • Cardiopulmonary

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by VA Office of Research and Development on 2025-11-10.