Recruiting

TMS

Sponsor:

Medical College of Wisconsin

Code:

NCT05425615

Conditions

Stroke

Aphasia

Language

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Transcranial Magnetic Stimulation

Study Details

Brief summary:

This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.

Conditions

Stroke

Aphasia

Language

Study ID

NCT05425615

Start date

Jun 5, 2024

Status verified date

Jul, 2026

Completion date

Jun, 2032

Anticipated

Primary completion date

Jun, 2032

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Diagnosed with left hemisphere stroke
  • Consent date >= 1 month after stroke onset
  • Right-handed
  • Fluent in English
  • 18 years of age or older

Exclusion Criteria:

  • Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
  • Non-decisional per decisionality questionnaire or other clinical assessment
  • Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
  • A chronic medical condition that is not treated or is unstable
  • Presence of

1. cardiac stimulators or pacemakers or intracardiac lines
2. neurostimulators
3. medication infusion device
4. any other implants near the scalp (e.g., cochlear implants) or in the eye
5. metal in the body
  • Pregnancy
  • History of skull fractures, or skin diseases
  • History of ongoing or unmanaged seizures or a family history of epilepsy
  • Presence of factors that potentially decrease seizure thresholds
  • On pro-convulsant medications
  • Untreated Sleep deprivation or insomnia
  • Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
  • History of dyslexia or other developmental learning disabilities

Study Design

Enrollment

135 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Active TMS

Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans (also known as an air-cooled coil) will be used for delivering active repetitive or rapid TMS to the target site.

active comparator: Control TMS

Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans will be used for delivering active repetitive or rapid TMS to the control site.

sham comparator: Sham TMS

Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans will be used for delivering sham repetitive or rapid TMS to the control or target site.

Interventions

Transcranial Magnetic Stimulation

Deymed DuoMag XT-100 rTMS

Primary outcome measure

  • Reaction time on language task performance [ Time Frame: Language tasks administered immediately before and/or after TMS administration (same day). ]
  • Accuracy on language task performance [ Time Frame: Language tasks administered immediately before and/or after TMS administration (same day). ]

Central Contacts and Locations

Central contacts

Sidney Schoenrock

414-955-7579sschoenrock@mcw.edu

Locations

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Sidney Schoenrock, MS

414-955-7579sschoenrock@mcw.edu

More Information

Sponsor

Medical College of Wisconsin

Last update posted

Jul 13, 2026

Last verified

Jul, 2026

Keywords

  • TMS
  • Transcranial Magnetic Stimulation
  • Aphasia
  • Semantic processing
  • Phonological processing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2026-07-13.