Recruiting

Observational Study

Sponsor:

Inova Health Care Services

Code:

NCT05433220

Conditions

Heart Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Best Practice Advisory using Electronic Health Record

Study Details

Brief summary:

A randomized, single-blind intervention trial to test the comparative effectiveness of an electronic health record best practice advisory system that informs clinicians of guideline-indicated and FDA-approved heart failure medications currently not prescribed to their patients with heart failure versus usual care (no alert and how things are done currently). The purpose of the alert is to stimulate appropriate medication prescription for patients with heart failure and a reduced ejection fraction. This will be done across outpatient Inova clinics and at the five Inova hospitals.

Conditions

Heart Failure

Study ID

NCT05433220

Start date

Aug 25, 2022

Status verified date

Jul, 2026

Completion date

Aug 25, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age>18 Years
  • Seen by a Cardiologist in an Inova clinic or Inova hospital setting
  • Left Ventricular Ejection Fraction ≤40%

Exclusion Criteria:

  • Opted out of EHR-based research
  • Hospice care
  • Already receiving maximally titrated doses of each of the four classes of evidence- based HFrEF medical therapy
  • Prior heart transplant

Study Design

Enrollment

5000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Alert when provider is entering orders

no intervention: No alert, usual care

Interventions

Best Practice Advisory using Electronic Health Record

Providers caring for patients randomized to the intervention arm will have a best practice alert appear for each of their eligible patients upon opening of the order entry screen in the patient's medical record. This alert informs the provider to the presence of HFrEF, notes the patient's current LVEF and current evidence-based medications, and gives access to an order set with recommended evidence- based, guideline-recommended, and FDA- approved therapies for patients with HFrEF. Providers will also have access to a link to best available guideline recommended information regarding treatment of heart failure to allow further education if desired by the provider. The alerts will also clearly state the expected monitoring and follow-up required for prescriptions of these medications.

Primary outcome measure

  • Increased use of GDMT in patients with Heart Failure with Reduced Ejection Fraction [ Time Frame: 30 days after randomization ]

Central Contacts and Locations

Central contacts

Matthew G Dimond, BS

7037762828matthew.dimond@inova.org

Bhruga Shah, MS, BSN-RN

7037762828Bhruga.Shah@inova.org

Locations

Inova Health System

Recruiting

Falls Church, Virginia, United States, 22042

Contacts

Matthew Dimond

703-776-6248matthew.dimond@inova.org

Bhruga Shah

7037762828Bhruga.shah@inova.org

More Information

Sponsor

Inova Health Care Services

Last update posted

Jul 13, 2026

Last verified

Jul, 2026

Keywords

  • Heart Failure
  • GDMT
  • NYHA
  • HFrEF
  • Implementation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Inova Health Care Services on 2026-07-13.