Recruiting

Memory Modulation

Sponsor:

UCLA

Code:

NCT05452122

Conditions

Memory, Delayed

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Auditory and Electrical Stimulation

Study Details

Brief summary:

The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.

Conditions

Memory, Delayed

Study ID

NCT05452122

Start date

Jul 13, 2022

Status verified date

Oct, 2025

Completion date

Aug 31, 2026

Anticipated

Primary completion date

Aug 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All epilepsy patients between the ages of 18 and 65 who undergo depth electrode placement for clinical purposes
  • Eligibility is determined by the epilepsy surgery team (based on neuropsychological testing and on psychiatric evaluation)
  • Willing to provide informed consent and participate the study

Exclusion Criteria:

  • Neurological or psychiatric issues, other than epilepsy, that would put the patient at risk
  • Patient is younger than 18 or older than 65 years of age
  • Unwilling to provide informed consent

Study Design

Enrollment

150 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Interventions

Auditory and Electrical Stimulation

Electrical and auditory stimulation will be applied during sleep.

Primary outcome measure

  • Recognition Accuracy [ Time Frame: 1-2 days contained within the participants' 1-2 week hospital stay; Specifically for each experiment, the outcome measure will be computed during the pre- and post-sleep memory tasks ]
  • Recognition Discriminability (D-prime) [ Time Frame: 1-2 days contained within the participants' 1-2 week hospital stay; Specifically for each experiment, the outcome measure will be computed during the pre- and post-sleep memory tasks. ]

Central Contacts and Locations

Central contacts

Andreina Hampton

3236105293amhampton@mednet.ucla.edu

Locations

University of California Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Andreina Hampton

3236105293amhampton@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Oct 14, 2025

Last verified

Oct, 2025

Keywords

  • sleep
  • stimulation
  • memory
  • learning
  • single-unit

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2025-10-14.